Areas of controversy in neuroprogression in bipolar disorder

IC Passos, B Mwangi, E Vieta, M Berk… - Acta Psychiatrica …, 2016 - Wiley Online Library
Objective We aimed to review clinical features and biological underpinnings related to
neuroprogression in bipolar disorder (BD). Also, we discussed areas of controversy and …

Physical activity modulates common neuroplasticity substrates in major depressive and bipolar disorder

C Phillips - Neural Plasticity, 2017 - Wiley Online Library
Mood disorders (MDs) are chronic, recurrent mental diseases that affect millions of
individuals worldwide. Although the biogenic amine model has provided some clinical utility …

Leukocyte telomere length in patients with bipolar disorder: an updated meta-analysis and subgroup analysis by mood status

YC Huang, LJ Wang, PT Tseng, CF Hung, PY Lin - Psychiatry research, 2018 - Elsevier
The purpose of the present meta-analysis was to compare leukocyte telomere length (LTL),
a proposed marker for cell aging, between patients with bipolar disorder (BD) and healthy …

Leukocyte telomere length positively correlates with duration of lithium treatment in bipolar disorder patients

A Squassina, C Pisanu, D Congiu, P Caria… - European …, 2016 - Elsevier
Bipolar disorder (BD) has been suggested to be associated with accelerated aging and
premature cell senescence. While findings on shorter telomeres in BD are controversial, a …

The way to a human's brain goes through their stomach: dietary factors in major depressive disorder

J Aly, O Engmann - Frontiers in neuroscience, 2020 - frontiersin.org
Globally, more than 250 million people are affected by depression (major depressive
disorder; MDD), a serious and debilitating mental disorder. Currently available treatment …

New advances in the pharmacology and toxicology of lithium: a neurobiologically oriented overview

A Bortolozzi, G Fico, M Berk, M Solmi, M Fornaro… - Pharmacological …, 2024 - ASPET
Over the last six decades, lithium has been considered the gold standard treatment for the
long-term management of bipolar disorder due to its efficacy in preventing both manic and …

Childhood trauma and mixed episodes are associated with poor response to lithium in bipolar disorders

B Etain, M Lajnef, C Brichant‐Petitjean… - Acta Psychiatrica …, 2017 - Wiley Online Library
Objectives Reliable predictors of response to lithium are still lacking in bipolar disorders (BD
s). However, childhood trauma has been hypothesized to be associated with poor response …

[HTML][HTML] Accelerated aging in bipolar disorders: An exploratory study of six epigenetic clocks

C Bourdon, B Etain, L Spano, R Belzeaux, M Leboyer… - Psychiatry …, 2023 - Elsevier
Bipolar disorder (BD) is a chronic and severe psychiatric disorder associated with significant
medical morbidity and reduced life expectancy. In this study, we assessed accelerated …

A call for improving lithium literacy among clinicians and patients

FA Gomes, E Brietzke, M Bauer, RM Post - International journal of bipolar …, 2022 - Springer
Despite overwhelming evidence that lithium prevents episodes of bipolar disorder and
suicide attempts and suicide,(Tondo et al. 2019) there has been a consistent decline in its …

Lithium and the interplay between telomeres and mitochondria in bipolar disorder

M Lundberg, V Millischer, L Backlund… - Frontiers in …, 2020 - frontiersin.org
Bipolar disorder is a severe psychiatric disorder which affects more than 1% of the world's
population and is a leading cause of disability among young people. For the past 50 years …