Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Rapid advances in sequencing technology have led to an explosive increase in the number
of genetic variants identified in patients with neurological disease and have also enabled …

Abstract AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic
glutamate receptors mediate fast excitatory neurotransmission throughout the central …

Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that open
their pores in response to binding of the agonist glutamate,–. An ionic current through a …

Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …

N-methyl-d-aspartate receptors (NMDARs) are transmembrane proteins that are activated by
the neurotransmitter glutamate and are found at most excitatory vertebrate synapses …

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the
majority of excitatory neurotransmission in the central nervous system. iGluRs open their ion …

Kainate receptors (KARs) are a subtype of ionotropic glutamate receptors that control
synaptic transmission in the central nervous system and are implicated in neurological …

NMDA receptors (NMDARs) are glutamate‐gated ion channels that contribute to nearly all
brain processes. Not surprisingly then, genetic variations in the genes encoding NMDAR …

AMPA receptors (AMPARs) mediate the majority of excitatory neurotransmission. Their
surface expression, trafficking, gating, and pharmacology are regulated by auxiliary …