Learning the chemical grammar of biomolecular condensates
HR Kilgore, RA Young - Nature chemical biology, 2022 - nature.com
Biomolecular condensates compartmentalize and regulate assemblies of biomolecules
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …
Targeting biomolecular condensation and protein aggregation against cancer
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …
separation, hold dichotomous roles in health and disease. Alongside their physiological …
Effects of pH alterations on stress-and aging-induced protein phase separation
X Jin, M Zhou, S Chen, D Li, X Cao, B Liu - Cellular and Molecular Life …, 2022 - Springer
Upon stress challenges, proteins/RNAs undergo liquid–liquid phase separation (LLPS) to
fine-tune cell physiology and metabolism to help cells adapt to adverse environments. The …
fine-tune cell physiology and metabolism to help cells adapt to adverse environments. The …
[HTML][HTML] Liquid-liquid phase separation of protein tau: An emerging process in Alzheimer's disease pathogenesis
H Ainani, N Bouchmaa, RB Mrid, R El Fatimy - Neurobiology of disease, 2023 - Elsevier
Metabolic reactions within cells occur in various isolated compartments with or without
borders, the latter being known as membrane-less organelles (MLOs). The MLOs show …
borders, the latter being known as membrane-less organelles (MLOs). The MLOs show …
Protein misfolding and amyloid nucleation through liquid–liquid phase separation
Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
[HTML][HTML] Phase separation in cancer: from the impacts and mechanisms to treatment potentials
Q Peng, S Tan, L Xia, N Wu, L Oyang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Cancer is a public health problem of great concern, and it is also one of the main causes of
death in the world. Cancer is a disease characterized by dysregulation of diverse cellular …
death in the world. Cancer is a disease characterized by dysregulation of diverse cellular …
Enhanced DNA repair through droplet formation and p53 oscillations
MS Heltberg, A Lucchetti, FS Hsieh, DPM Nguyen… - Cell, 2022 - cell.com
Living organisms are constantly exposed to DNA damage, and optimal repair is therefore
crucial. A characteristic hallmark of the response is the formation of sub-compartments …
crucial. A characteristic hallmark of the response is the formation of sub-compartments …
Melatonin: regulation of biomolecular condensates in neurodegenerative disorders
Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …
chemically distinct subcellular compartments organizing macromolecules such as proteins …
Phase separation in cancer at a glance
Q Xie, J Cheng, W Mei, D Yang, P Zhang… - Journal of Translational …, 2023 - Springer
Eukaryotic cells are segmented into multiple compartments or organelles within the cell that
regulate distinct chemical and biological processes. Membrane-less organelles are …
regulate distinct chemical and biological processes. Membrane-less organelles are …
From a Droplet to a Fibril and from a Fibril to a Droplet: Intertwined Transition Pathways in Highly Dynamic Enzyme-Modulated Peptide-Adenosine Triphosphate …
Many cellular coassemblies of proteins and polynucleotides facilitate liquid–liquid phase
separation (LLPS) and the subsequent self-assembly of disease-associated amyloid fibrils …
separation (LLPS) and the subsequent self-assembly of disease-associated amyloid fibrils …