Learning the chemical grammar of biomolecular condensates

HR Kilgore, RA Young - Nature chemical biology, 2022 - nature.com
Biomolecular condensates compartmentalize and regulate assemblies of biomolecules
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …

Targeting biomolecular condensation and protein aggregation against cancer

JL Silva, D Foguel, VF Ferreira, TCRG Vieira… - Chemical …, 2023 - ACS Publications
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Effects of pH alterations on stress-and aging-induced protein phase separation

X Jin, M Zhou, S Chen, D Li, X Cao, B Liu - Cellular and Molecular Life …, 2022 - Springer
Upon stress challenges, proteins/RNAs undergo liquid–liquid phase separation (LLPS) to
fine-tune cell physiology and metabolism to help cells adapt to adverse environments. The …

[HTML][HTML] Liquid-liquid phase separation of protein tau: An emerging process in Alzheimer's disease pathogenesis

H Ainani, N Bouchmaa, RB Mrid, R El Fatimy - Neurobiology of disease, 2023 - Elsevier
Metabolic reactions within cells occur in various isolated compartments with or without
borders, the latter being known as membrane-less organelles (MLOs). The MLOs show …

Protein misfolding and amyloid nucleation through liquid–liquid phase separation

S Mukherjee, M Poudyal, K Dave, P Kadu… - Chemical Society …, 2024 - pubs.rsc.org
Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …

[HTML][HTML] Phase separation in cancer: from the impacts and mechanisms to treatment potentials

Q Peng, S Tan, L Xia, N Wu, L Oyang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Cancer is a public health problem of great concern, and it is also one of the main causes of
death in the world. Cancer is a disease characterized by dysregulation of diverse cellular …

Enhanced DNA repair through droplet formation and p53 oscillations

MS Heltberg, A Lucchetti, FS Hsieh, DPM Nguyen… - Cell, 2022 - cell.com
Living organisms are constantly exposed to DNA damage, and optimal repair is therefore
crucial. A characteristic hallmark of the response is the formation of sub-compartments …

Melatonin: regulation of biomolecular condensates in neurodegenerative disorders

D Loh, RJ Reiter - Antioxidants, 2021 - mdpi.com
Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …

Phase separation in cancer at a glance

Q Xie, J Cheng, W Mei, D Yang, P Zhang… - Journal of Translational …, 2023 - Springer
Eukaryotic cells are segmented into multiple compartments or organelles within the cell that
regulate distinct chemical and biological processes. Membrane-less organelles are …

From a Droplet to a Fibril and from a Fibril to a Droplet: Intertwined Transition Pathways in Highly Dynamic Enzyme-Modulated Peptide-Adenosine Triphosphate …

R Dec, W Dzwolak, R Winter - Journal of the American Chemical …, 2024 - ACS Publications
Many cellular coassemblies of proteins and polynucleotides facilitate liquid–liquid phase
separation (LLPS) and the subsequent self-assembly of disease-associated amyloid fibrils …