Abstract 30 years after the identification of WNTs, their signal transduction has become
increasingly complex, with the discovery of more than 15 receptors and co-receptors in …

Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and
tissue homeostasis. Misregulation of intracellular signal transduction can lead to …

The Wnt family of secreted ligands act through many receptors to stimulate distinct
intracellular signalling pathways in embryonic development, in adults and in disease …

Wnt signaling controls a variety of developmental and homeostatic events. As a key
component of Wnt signaling, Dishevelled (Dvl/Dsh) protein relays Wnt signals from receptors …

For more than a decade, Wnt signaling pathways have been the focus of intense research
activity in bone biology laboratories because of their importance in skeletal development …

An unanswered question in the field of signal transduction research is how different
signaling pathways are activated with strict specificity in a temporally and spatially controlled …

In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a
variety of other responses. These are often lumped together under the denominator …

Receptor tyrosine kinases of the Ryk and Ror families were initially classified as orphan
receptors because their ligands were unknown. They are now known to contain functional …

Determining how axon guidance receptors transmit signals to allow precise pathfinding
decisions is fundamental to our understanding of nervous system development and may …

Wnt signaling function starts during the development of the nervous system and is crucial for
synaptic plasticity in the adult brain. Clearly Wnt effects in synaptic and plastic processes are …