[HTML][HTML] Advances in the engineering of the outer blood-retina barrier: From in-vitro modelling to cellular therapy

C Dujardin, W Habeler, C Monville, D Letourneur… - Bioactive Materials, 2024 - Elsevier
The outer blood-retina barrier (oBRB), crucial for the survival and the proper functioning of
the overlying retinal layers, is disrupted in numerous diseases affecting the retina, leading to …

Generation of a 3D Outer Blood–Retinal Barrier with Advanced Choriocapillaris and Its Application in Diabetic Retinopathy in a Microphysiological System

U Nam, S Lee, JS Jeon - ACS Biomaterials Science & Engineering, 2023 - ACS Publications
The outer blood–retinal barrier (oBRB) provides an optimal environment for the function of
the photoreceptor by regulating the exchange of molecules between subretinal space and …

Microphysiological Systems as Organ-Specific In Vitro Vascular Models for Disease Modeling

U Nam, S Lee, A Ahmad, H Yi, JS Jeon - BioChip Journal, 2024 - Springer
The vascular system, essential for human physiology, is vital for transporting nutrients,
oxygen, and waste. Since vascular structures are involved in various disease pathogeneses …

Biomaterial engineering strategies for modeling the Bruch's membrane in age-related macular degeneration

B Molins, A Rodríguez, V Llorenç… - Neural Regeneration …, 2024 - journals.lww.com
Age-related macular degeneration, a multifactorial inflammatory degenerative retinal
disease, ranks as the leading cause of blindness in the elderly. Strikingly, there is a scarcity …

年龄相关性黄斑变性布鲁赫膜模型的生物材料工程策略

B Molins, A Rodríguez, V Llorenç… - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
Age-related macular degeneration, a multifactorial inflammatory degenerative retinal
disease, ranks as the leading cause of blindness in the elderly. Strikingly, there is a scarcity …

[PDF][PDF] Development and implementation of next-generation Retina-on-Chip platforms

J Chuchuy - 2024 - d-nb.info
The human retina is the key element for light detection and plays a pivotal role in our visual
system. Retinal damages and diseases significantly hamper the daily life of affected …

[PDF][PDF] Bioengineering an Optimised in vitro Model of the Outer Blood-Retinal Barrier Under Diabetic-like Conditions for the Screening of Novel Pharmacological …

G Lugano - 2023 - livrepository.liverpool.ac.uk
Introduction: eye diseases caused by diabetes, such as diabetic retinopathy and diabetic
oedema can lead to sight loss, significantly reducing the quality of life and economic …