Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications

YH Chung, H Cai, NF Steinmetz - Advanced Drug Delivery Reviews, 2020 - Elsevier
Viral nanoparticles (VNPs) encompass a diverse array of naturally occurring nanomaterials
derived from plant viruses, bacteriophages, and mammalian viruses. The application and …

Application of plant viruses in biotechnology, medicine, and human health

S Venkataraman, K Hefferon - Viruses, 2021 - mdpi.com
Plant-based nanotechnology programs using virus-like particles (VLPs) and virus
nanoparticles (VNPs) are emerging platforms that are increasingly used for a variety of …

Enhanced stability and controlled delivery of MOF-encapsulated vaccines and their immunogenic response in vivo

MA Luzuriaga, RP Welch… - … applied materials & …, 2019 - ACS Publications
Vaccines have an innate tendency to lose their structural conformation upon environmental
and chemical stressors. A loss in conformation reduces the therapeutic ability to prevent the …

PhotothermalPhage: a virus-based photothermal therapeutic agent

A Shahrivarkevishahi, MA Luzuriaga… - Journal of the …, 2021 - ACS Publications
Virus-like particles (VLPs) are multifunctional nanocarriers that mimic the architecture of
viruses. They can serve as a safe platform for specific functionalization and immunization …

Cell morphology-based machine learning models for human cell state classification

Y Li, CM Nowak, U Pham, K Nguyen… - NPJ systems biology and …, 2021 - nature.com
Herein, we implement and access machine learning architectures to ascertain models that
differentiate healthy from apoptotic cells using exclusively forward (FSC) and side (SSC) …

Functional polymers as metal-free magnetic resonance imaging contrast agents

C Fu, Y Yu, X Xu, Q Wang, Y Chang, C Zhang… - Progress in Polymer …, 2020 - Elsevier
Magnetic resonance imaging (MRI) is recognized as the most powerful clinical imaging
modality due to its ability to generate detailed three-dimensional anatomical images with …

Plant viruses and bacteriophage-based reagents for diagnosis and therapy

S Shukla, H Hu, H Cai, SK Chan… - Annual review of …, 2020 - annualreviews.org
Viral nanotechnology exploits the prefabricated nanostructures of viruses, which are already
abundant in nature. With well-defined molecular architectures, viral nanocarriers offer …

Nanocarrier-based drug delivery system for cancer therapeutics: a review of the last decade

M Sohail, W Guo, Z Li, H Xu, F Zhao… - Current Medicinal …, 2021 - ingentaconnect.com
In recent years, due to the shortcomings of conventional chemotherapy, such as poor
bioavailability, low treatment index, and unclear side effects, the focus of cancer research …

Physalis mottle virus-like nanoparticles for targeted cancer imaging

H Hu, H Masarapu, Y Gu, Y Zhang, X Yu… - … applied materials & …, 2019 - ACS Publications
One of the greatest challenges in nanomedicine is the low efficiency with which
nanoparticles are delivered to lesions such as tumors in vivo. Here, we show that Physalis …

Supramolecular encapsulation of small-ultrared fluorescent proteins in virus-like nanoparticles for noninvasive in vivo imaging agents

FC Herbert, OR Brohlin, T Galbraith… - Bioconjugate …, 2020 - ACS Publications
Icosahedral virus-like particles (VLPs) derived from bacteriophages Qβ and PP7
encapsulating small-ultrared fluorescent protein (smURFP) were produced using a versatile …