Background Nowadays, conventional medical treatments such as surgery, radiotherapy, and
chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is …

For glioblastoma, the tumor microenvironment (TME) is pivotal to support tumor progression
and therapeutic resistance. TME consists of several types of stromal, endothelial and …

Simple Summary Glioblastoma multiforme (GBM) are among the most lethal tumors. The
highly invasive nature and presence of GBM stem cells, as well as the blood brain barrier …

Glioblastoma (GBM) is one of the most common, deadly, and difficult-to-treat adult brain
tumors. Surgical removal of the tumor, followed by radiotherapy (RT) and temozolomide …

Gliomas, and in particular glioblastoma multiforme, are aggressive brain tumors
characterized by a poor prognosis and high rates of recurrence. Current treatment strategies …

Abstract Lysosomal Storage Disorders (LSDs) are a diverse group of inherited, monogenic
diseases caused by functional defects in specific lysosomal proteins. The lysosome is a …

The last two decades have witnessed explosive growth in the field of nanoengineering and
nanomedicine. In particular, engineered nanoparticles have garnered great attention due to …

Purpose Glioblastoma (GBM) is a devastating disease. With the current treatment of surgery
followed by chemoradiation, outcomes remain poor, with median survival of only 15 months …

Highlights•Peptides have a potential for ligand-mediated targeting and drug
delivery.•Peptides can inhibit dysregulated signaling pathways and kill cancer cells.•Some …

Discriminatory drug delivery into target cells is essential to effectively elicit the drug activity
and to avoid off-target side effects; however, transporting drugs across the cell membrane is …