The ability to construct a peptide or protein in a spatio-specific manner is of great interest for
therapeutic and biochemical research. However, the various functional groups present in …

The importance of modified peptides and proteins for applications in drug discovery, and for
illuminating biological processes at the molecular level, is fueling a demand for efficient …

Rapid and in-depth exploration of the chemical space of high-molecular-weight synthetic
polypeptides via ring-opening polymerization of N-carboxyanhydride allows the discovery of …

Mild strategies for the selective modification of peptides and proteins are in demand for
applications in therapeutic peptide and protein discovery, and in the study of fundamental …

Bioconjugation techniques for biomolecule–polymer conjugation are numerous; however,
slow kinetics and steric challenges generally necessitate excess reagents or long reaction …

Efficient functionalization of peptides and proteins has widespread applications in chemical
biology and drug discovery. However, the chemoselective and site-selective modification of …

Proteins are the most abundant biomolecules in nature and are involved almost in all living
processes. Chemical modification of proteins is an efficient strategy to mediate and study the …

Click chemistry is a powerful molecular assembly strategy for rapid functional discovery. The
development of click reactions with new connecting linkage is of great importance for …

Selenoprotein F (SelF) is an endoplasmic reticulum-residing eukaryotic protein that contains
a selenocysteine (Sec) residue. It has been suggested to be involved in a number of …

Cu (II)-mediated C–H sulphenylation or selenylation of Trp indole by a derivative of cysteine
or selenocysteine enables access to the tryptathionine unit or its selenium congener. The …