Cancer proteogenomics: current impact and future prospects

DR Mani, K Krug, B Zhang, S Satpathy… - Nature Reviews …, 2022 - nature.com
Genomic analyses in cancer have been enormously impactful, leading to the identification of
driver mutations and development of targeted therapies. But the functions of the vast majority …

CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2011–2015

QT Ostrom, H Gittleman, G Truitt, A Boscia… - Neuro …, 2018 - academic.oup.com
Background CBTRUS is a unique professional research organization that focuses
exclusively on providing high-quality statistical data on the population-based incidence of …

CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2015–2019

QT Ostrom, M Price, C Neff, G Cioffi, KA Waite… - Neuro …, 2022 - academic.oup.com
Abstract The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration
with the Centers for Disease Control and Prevention and the National Cancer Institute, is the …

CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013–2017

QT Ostrom, N Patil, G Cioffi, K Waite, C Kruchko… - Neuro …, 2020 - academic.oup.com
Abstract The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration
with the Centers for Disease Control (CDC) and National Cancer Institute (NCI), is the …

CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2014–2018

QT Ostrom, G Cioffi, K Waite, C Kruchko… - Neuro …, 2021 - academic.oup.com
Abstract The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration
with the Centers for Disease Control and Prevention (CDC) and National Cancer Institute …

Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

M Wong, C Mayoh, LMS Lau, DA Khuong-Quang… - Nature medicine, 2020 - nature.com
Abstract The Zero Childhood Cancer Program is a precision medicine program to benefit
children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline …

CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2012–2016

QT Ostrom, G Cioffi, H Gittleman, N Patil… - Neuro …, 2019 - academic.oup.com
Abstract The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration
with the Centers for Disease Control and Prevention and National Cancer Institute, is the …

[PDF][PDF] Integrated proteogenomic characterization across major histological types of pediatric brain cancer

F Petralia, N Tignor, B Reva, M Koptyra, S Chowdhury… - Cell, 2020 - cell.com
We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

The chromatin accessibility landscape of primary human cancers

MR Corces, JM Granja, S Shams, BH Louie… - Science, 2018 - science.org
INTRODUCTION Cancer is one of the leading causes of death worldwide. Although the 2%
of the human genome that encodes proteins has been extensively studied, much remains to …

Leveraging base-pair mammalian constraint to understand genetic variation and human disease

PF Sullivan, JRS Meadows, S Gazal, BDN Phan, X Li… - Science, 2023 - science.org
Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …