Human skin acts as a primary barrier between the body and its environment. Crucial for this
skin barrier function is the lipid matrix in the outermost layer of the skin, the stratum corneum …

Skin barrier dysfunction caused by endogenous or exogenous factors can lead to various
disorders such as xerosis cutis, ichthyoses, and atopic dermatitis. Filaggrin is a pivotal …

Epithelial barriers of the skin, gastrointestinal tract, and airway serve common critical
functions, such as maintaining a physical barrier against environmental insults and …

The skin is constantly exposed to various endogenous and exogenous factors that may
impact the barrier function at the physical, mechanical, and microbial levels. These factors …

Ceramides play an essential role in forming a permeability barrier in the skin. Atopic
dermatitis (AD) is a common chronic skin disease associated with skin barrier dysfunction …

Background Adiponectin is known to take part in the regulation of energy metabolism.
AdipoRon, an orally-active synthetic adiponectin agonist, binds to both adiponectin …

Atopic Dermatitis (AD) is an extremely pruritic inflammatory skin disease that has a
worldwide prevalence of approximately 2.69%, with significant variability by country. 1 In the …

Background Specific species of ceramides (Cer), major constituents of lipids in the stratum
corneum (SC), are decreased and are correlated with SC barrier and water-holding …

Accumulation of lipids and their metabolites induces lipotoxicity in diabetic cardiomyopathy.
Lowering ceramide concentration could reduce the impact of metabolic damage to target …

The skin is an organ involved in several biological processes essential to the proper
functioning of the organism. One of these essential biological functions of the skin is its …