[HTML][HTML] Fibroblasts: Origins, definitions, and functions in health and disease
Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …
disease by producing complex extracellular matrix and creating signaling niches through …
[HTML][HTML] Multipotent stromal cells: one name, multiple identities
Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …
regeneration of most tissues. They can differentiate along multiple connective lineages, but …
[HTML][HTML] Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer
Adult mammalian skin wounds heal by forming fibrotic scars. We report that full-thickness
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar …
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar …
Local and systemic mechanisms that control the hair follicle stem cell niche
B Zhang, T Chen - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Hair follicles are essential appendages of the mammalian skin, as hair performs vital
functions of protection, thermoregulation and sensation. Hair follicles harbour exceptional …
functions of protection, thermoregulation and sensation. Hair follicles harbour exceptional …
[HTML][HTML] Distinct regulatory programs control the latent regenerative potential of dermal fibroblasts during wound healing
Dermal fibroblasts exhibit considerable heterogeneity during homeostasis and in response
to injury. Defining lineage origins of reparative fibroblasts and regulatory programs that drive …
to injury. Defining lineage origins of reparative fibroblasts and regulatory programs that drive …
Prrx1 marks stem cells for bone, white adipose tissue and dermis in adult mice
H Liu, P Li, S Zhang, J Xiang, R Yang, J Liu… - Nature Genetics, 2022 - nature.com
Specialized connective tissues, including bone and adipose tissues, control various
physiological activities, including mineral and energy homeostasis. However, the identity of …
physiological activities, including mineral and energy homeostasis. However, the identity of …
Novel insights from a multiomics dissection of the Hayflick limit
The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …
senescence has become a prominent model for cellular aging in vitro. Despite decades of …
Building and maintaining the skin
YC Hsu, E Fuchs - Cold Spring Harbor perspectives in …, 2022 - cshperspectives.cshlp.org
The skin forms a crucial, dynamic barrier between an animal and the external world. In
mammals, three stem cell populations possess robust regenerative potential to maintain and …
mammals, three stem cell populations possess robust regenerative potential to maintain and …
Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state
Y Liu, CF Guerrero-Juarez, F Xiao, NU Shettigar… - Developmental cell, 2022 - cell.com
Hair follicle stem cells are regulated by dermal papilla fibroblasts, their principal signaling
niche. Overactivation of Hedgehog signaling in the niche dramatically accelerates hair …
niche. Overactivation of Hedgehog signaling in the niche dramatically accelerates hair …
Skin fibroblast functional heterogeneity in health and disease
T Bensa, S Tekkela, E Rognoni - The Journal of Pathology, 2023 - Wiley Online Library
Fibroblasts are the major cell population of connective tissue, including the skin dermis, and
are best known for their function in depositing and remodelling the extracellular matrix …
are best known for their function in depositing and remodelling the extracellular matrix …