Hepatorenal syndrome (HRS), the extreme manifestation of renal impairment in patients with
cirrhosis, is characterized by reduction in renal blood flow and glomerular filtration rate …

Portal hypertension, defined as increased pressure in the portal vein, develops as a
consequence of increased intrahepatic vascular resistance due to the dysregulation of liver …

Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …

Relaxin is an antifibrotic peptide hormone previously assumed to directly reverse the
activation of hepatic stellate cells for liver fibrosis resolution. Using nanoparticle-mediated …

Liver diseases such as hepatitis, cirrhosis, and hepatocellular carcinoma are global health
problems accounting for approximately 800 million cases and over 2 million deaths per year …

Nitric oxide (NO) and its derivatives play important roles in the physiology and
pathophysiology of the liver. Despite its diverse and complicated roles, certain patterns of …

In chronic liver diseases, an ongoing hepatocellular injury together with inflammatory
reaction results in activation of hepatic stellate cells (HSCs) and increased deposition of …

Over the past two decades the advances in molecular cell biology have led to significant
discoveries about the pathophysiology of portal hypertension (PHT). In particular, great …

Fibrosis refers to the hardening or scarring of tissues that usually results from aberrant
wound healing in response to organ injury, and its manifestations in various organs have …

Liver fibrosis is a reversible disease course caused by various liver injury etiologies, and it
can lead to severe complications, such as liver cirrhosis, liver failure, and even liver cancer …