In recent years, a link between the transcriptional regulators of lineage-specific gene
expression and progenitor proliferation control has emerged. A main exponent of this …

The vertebrate lung consists of multiple cell types that are derived primarily from endodermal
and mesodermal compartments of the early embryo. The process of pulmonary …

The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model …

Stem cell function is central for the maintenance of normal tissue homeostasis. Here we
show that deletion of p38α mitogen-activated protein (MAP) kinase in adult mice results in …

While much is known about aberrant pathways affecting cell growth and apoptosis, our
understanding of another critical step of neoplastic transformation, differentiation arrest …

The transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα) plays a critical
role during embryogenesis and is thereafter required for homeostatic glucose metabolism …

Lung cancer is the leading cause of cancer death in the world today and is poised to claim
approximately 1 billion lives during the 21st century. A major challenge in treating this and …

Neutrophilic differentiation is dependent on CCAAT enhancer-binding protein α (C/EBPα), a
transcription factor expressed in multiple organs including the bone marrow. Using …

Coactivator-associated arginine methyltransferase I (CARM1; PRMT4) regulates gene
expression by multiple mechanisms including methylation of histones and coactivation of …

Lung cancer is the most common cause of cancer deaths. The expression of the
transcription factor C/EBPα (CCAAT/enhancer binding protein α) is frequently lost in non …