microRNAs in action: biogenesis, function and regulation
Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …
years ago, a broad community of researchers was drawn to investigate the universe of small …
Long non-coding RNA structure and function: is there a link?
A Zampetaki, A Albrecht, K Steinhofel - Frontiers in physiology, 2018 - frontiersin.org
RNA has emerged as the prime target for diagnostics, therapeutics and the development of
personalized medicine. In particular, the non-coding RNAs (ncRNAs) that do not encode …
personalized medicine. In particular, the non-coding RNAs (ncRNAs) that do not encode …
Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges
Clustered regulatory interspaced short palindromic repeats (CRISPR) has changed
biomedical research and provided entirely new models to analyze every aspect of …
biomedical research and provided entirely new models to analyze every aspect of …
[HTML][HTML] Epithelial miR-141 regulates IL-13–induced airway mucus production
S Siddiqui, K Johansson, A Joo, LR Bonser, KD Koh… - JCI insight, 2021 - ncbi.nlm.nih.gov
IL-13–induced goblet cell metaplasia contributes to airway remodeling and pathological
mucus hypersecretion in asthma. miRNAs are potent modulators of cellular responses, but …
mucus hypersecretion in asthma. miRNAs are potent modulators of cellular responses, but …
MicroRNA clustering assists processing of suboptimal microRNA hairpins through the action of the ERH protein
Microprocessor initiates the processing of microRNAs (miRNAs) from the hairpin regions of
primary transcripts (pri-miRNAs). Pri-miRNAs often contain multiple miRNA hairpins, and …
primary transcripts (pri-miRNAs). Pri-miRNAs often contain multiple miRNA hairpins, and …
miRNAs: The Key Regulator of COVID‐19 Disease
LT Hardin, N Xiao - International Journal of Cell Biology, 2022 - Wiley Online Library
As many parts of the world continue to fight the innumerable waves of COVID‐19 infection,
SARS‐CoV‐2 continues to sculpt its antigenic determinants to enhance its virulence and …
SARS‐CoV‐2 continues to sculpt its antigenic determinants to enhance its virulence and …
SAFB2 enables the processing of suboptimal stem-loop structures in clustered primary miRNA transcripts
K Hutter, M Lohmüller, A Jukic, F Eichin, S Avci, V Labi… - Molecular cell, 2020 - cell.com
Many microRNAs (miRNAs) are generated from primary transcripts containing multiple
clustered stem-loop structures that are thought to be recognized and cleaved by the …
clustered stem-loop structures that are thought to be recognized and cleaved by the …
Post‐transcriptional regulation of polycistronic microRNAs
M Vilimova, S Pfeffer - Wiley Interdisciplinary Reviews: RNA, 2023 - Wiley Online Library
An important proportion of microRNA (miRNA) genes tend to lie close to each other within
animal genomes. Such genomic organization is generally referred to as miRNA clusters …
animal genomes. Such genomic organization is generally referred to as miRNA clusters …
ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8
The microprocessor complex cleaves the primary transcript of microRNA (pri-miRNA) to
initiate miRNA maturation. Microprocessor is known to consist of RNase III DROSHA and …
initiate miRNA maturation. Microprocessor is known to consist of RNase III DROSHA and …
Genomic clustering facilitates nuclear processing of suboptimal pri-miRNA loci
Nuclear processing of most miRNAs is mediated by Microprocessor, comprised of RNase III
enzyme Drosha and its cofactor DGCR8. Here, we uncover a hidden layer of Microprocessor …
enzyme Drosha and its cofactor DGCR8. Here, we uncover a hidden layer of Microprocessor …