Living organisms use a large repertoire of anabolic and catabolic reactions to maintain their
physiological body functions, many of which include oxidation and reduction of substrates …

Glutathione (GSH) is a tripeptide, which has many biological roles including protection
against reactive oxygen and nitrogen species. The primary goal of this paper is to …

Redox homeostasis governs a number of critical cellular processes. In turn, imbalances in
pathways that control oxidative and reductive conditions have been linked to a number of …

S-glutathionylation, the post-translational modification forming mixed disulfides between
protein reactive thiols and glutathione, regulates redox-based signaling events in the cell …

Glutathione (GSH) is the most abundant antioxidant and a major detoxification agent in cells.
It is synthesized through two-enzyme reaction catalyzed by glutamate cysteine ligase and …

Reactive oxygen species were discovered in living organisms in the early 1950's and their
action has been implicated in diverse biological processes. First formulated by H. Sies in …

BACKGROUND: It is now recognized that protein cysteines exist not only as free thiols or
intramolecular disulfides, that help maintain the 3D structure of proteins, but can also …

Studies done many years ago established unequivocally the key role of calcium as a
universal second messenger. In contrast, the second messenger roles of reactive oxygen …

8-Oxoguanine (8-oxoG), a common and mutagenic form of oxidized guanine in DNA, is
eliminated mainly through base excision repair. In human cells its repair is initiated by …

In addition to protein phosphorylation, redox-dependent posttranslational modification of
proteins is emerging as a key signaling system, conserved throughout evolution, and …