Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

In eukaryotic genomes, transcriptional machinery and nucleosomes compete for binding to
DNA sequences; thus, a crucial aspect of gene regulatory element function is to modulate …

Chromatin accessibility is integral to the process by which transcription factors (TFs) read out
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …

Previous studies have identified topologically associating domains (TADs) as basic units of
genome organization. We present evidence of a previously unreported level of genome …

Boundaries in animal genomes delimit contact domains with enhanced internal contact
frequencies and have debated functions in limiting regulatory cross-talk between domains …

While the accessibility of enhancers is dynamically regulated during development,
promoters tend to be constitutively accessible and poised for activation by paused Pol II. By …

Chromatin loops between gene pairs have been observed in diverse contexts in both flies
and vertebrates. Combining high-resolution Capture-C, DNA fluorescence in situ …

A key problem in development is to understand how genes turn on or off at the right place
and right time during embryogenesis. Such decisions are made by non-coding sequences …

Precise patterns of gene expression are driven by interactions between transcription factors,
regulatory DNA sequences, and chromatin. How DNA mutations affecting any one of these …

Chromatin accessibility sequencing has been widely used for uncovering genetic regulatory
mechanisms and inferring gene regulatory networks. However, effectively integrating large …