CRISPR-based diagnostics

MM Kaminski, OO Abudayyeh, JS Gootenberg… - Nature Biomedical …, 2021 - nature.com
The accurate and timely diagnosis of disease is a prerequisite for efficient therapeutic
intervention and epidemiological surveillance. Diagnostics based on the detection of nucleic …

Significance and clinical management of persistent low-level viremia and very-low-level viremia in HIV-1-infected patients

P Ryscavage, S Kelly, JZ Li, PR Harrigan… - Antimicrobial agents …, 2014 - Am Soc Microbiol
ABSTRACT A goal of HIV therapy is to sustain suppression of the plasma viral load below
the detection limits of clinical assays. However, widely followed treatment guidelines diverge …

[HTML][HTML] Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label …

S McCormack, DT Dunn, M Desai, DI Dolling, M Gafos… - The Lancet, 2016 - thelancet.com
Background Randomised placebo-controlled trials have shown that daily oral pre-exposure
prophylaxis (PrEP) with tenofovir–emtricitabine reduces the risk of HIV infection. However …

British HIV Association guidelines for the treatment of HIV‐1‐positive adults with antiretroviral therapy 2012 (Updated November 2013. All changed text is cast in …

Writing Group, I Williams, D Churchill… - HIV …, 2014 - Wiley Online Library
1.4 Resource use 1.5 Implications for research 1.6 References 2.0 Recommendations and
auditable outcomes 2.1 Recommendations (GRADE) 2.1. 1 Patient involvement in decision …

Recommendations for evaluation and management of bone disease in HIV

TT Brown, J Hoy, M Borderi, G Guaraldi… - Clinical Infectious …, 2015 - academic.oup.com
Thirty-four human immunodeficiency virus (HIV) specialists from 16 countries contributed to
this project, whose primary aim was to provide guidance on the screening, diagnosis, and …

HIV virologic failure and its predictors among HIV-infected adults on antiretroviral therapy in the African Cohort Study

F Kiweewa, A Esber, E Musingye, D Reed, TA Crowell… - PloS one, 2019 - journals.plos.org
Introduction The 2016 WHO consolidated guidelines on the use of antiretroviral drugs
defines HIV virologic failure for low and middle income countries (LMIC) as plasma HIV …

[HTML][HTML] Viral suppression after 12 months of antiretroviral therapy in low-and middle-income countries: a systematic review

JH McMahon, JH Elliott, S Bertagnolio… - Bulletin of the World …, 2013 - SciELO Public Health
OBJECTIVE: To establish estimates of viral suppression in low-and middle-income countries
(LMICs) in patients who received antiretroviral therapy (ART) for human immunodeficiency …

CRISPR Cas12a-powered silicon surface-enhanced raman spectroscopy ratiometric chip for sensitive and reliable quantification

H Cao, J Xie, J Cheng, Y Xu, X Lu, J Tang… - Analytical …, 2023 - ACS Publications
Sensitive and reliable clustered regularly interspaced short palindromic repeats (CRISPR)
quantification without preamplification of the sample remains a challenge. Herein, we report …

Antiretrovirals and the kidney in current clinical practice: renal pharmacokinetics, alterations of renal function and renal toxicity

JC Yombi, A Pozniak, M Boffito, R Jones, S Khoo… - Aids, 2014 - journals.lww.com
Assessment of renal function in HIV-positive patients is of increasing importance in the
context of ageing and associated comorbidities. Exposure to nephrotoxic medications is …

Scaling-up PrEP delivery in sub-Saharan Africa: what can we learn from the scale-up of ART?

G O'Malley, G Barnabee, K Mugwanya - Current HIV/AIDS Reports, 2019 - Springer
Abstract Purpose of Review Clinical trials have found that PrEP is highly effective in
reducing risk of HIV acquisition across types of exposure, gender, PrEP regimens, and …