Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …

Rapid advances in genomics have opened unprecedented possibilities to explore the
mutational landscapes in malignant diseases, such as B-cell acute lymphoblastic leukemia …

Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) generate all cells of
the blood system. Despite their multipotency, MPPs display poorly understood lineage bias …

While PAX5 is an important tumor suppressor gene in B‐cell acute lymphoblastic leukemia
(B‐ALL), it is also involved in oncogenic translocations coding for diverse PAX5 fusion …

Genes encoding B lineage–restricted transcription factors are frequently mutated in B-
lymphoid leukemias, suggesting a close link between normal and malignant B-cell …

PAX5, a master regulator of B cell development and maintenance, is one of the most
common targets of genetic alterations in B-cell acute lymphoblastic leukemia (B-ALL). PAX5 …

B cell acute lymphoblastic leukemia (B-ALL) is a multistep disease characterized by the
hierarchical acquisition of genetic alterations. However, the question of how a primary …

The contribution of three-dimensional genome organization to physiological ageing is not
well known. Here we show that large-scale chromatin reorganization distinguishes young …

B lymphopoiesis is orchestrated by lineage-specific transcription factors. In B cell
progenitors, lineage commitment is mediated by Pax5, which is commonly mutated in B cell …

Centrioles define centrosome structure and function. Deregulation of centriole numbers can
cause developmental defects and cancer. The p53 tumor suppressor limits the growth of …