Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance

Z Guo, M Ashrafizadeh, W Zhang, R Zou… - Cancer and metastasis …, 2024 - Springer
The metastasis is a multistep process in which a small proportion of cancer cells are
detached from the colony to enter into blood cells for obtaining a new place for metastasis …

MicroRNAs as biomarkers and perspectives in the therapy of pancreatic cancer

T Xia, XY Chen, YN Zhang - Molecular and Cellular Biochemistry, 2021 - Springer
Pancreatic cancer is considered as one of the most aggressive tumor types, representing
over 45,750 mortality cases annually in the USA solely. The aggressive nature and late …

[HTML][HTML] Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells

AH Lee, D Ghosh, IL Koh, MR Dawson - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Radiation-induced fibrosis is a common side effect of radiotherapy, which is the most
common treatment for cancer. However, radiation also causes p53-mediated cell cycle …

Exosome‐Mediated Transfer of miR‐3613‐5p Enhances Doxorubicin Resistance by Suppression of PTEN Expression in Breast Cancer Cells

L Luo, X Zhang, Y Rousuli, A Aini - Journal of Oncology, 2022 - Wiley Online Library
Breast cancer is the most common malignancy among women worldwide, and patients
easily develop resistance to the first‐line drug doxorubicin. To elucidate the molecular …

The pharmacological actions of Danzhi-xiaoyao-San on depression involve lysophosphatidic acid and microbiota-gut-brain axis: novel insights from a systems …

X Zhu, S Wu, Y Zhou, T Xiao, L Xia… - Journal of …, 2024 - Taylor & Francis
Abstract Danzhi-xiaoyao-San (DZXYS), a Traditional Chinese Medicine, plays an essential
role in the clinical treatment of depression, but its mechanisms in humans remain unclear …

Interleukin-33 mediated regulation of microRNAs in human cord blood-derived mast cells: Implications for infection, immunity, and inflammation

S Bakhashab, GH Banafea, F Ahmed, N Bagatian… - PloS one, 2024 - journals.plos.org
Mast cell (MCs) activation is the driving force of immune responses in several inflammatory
diseases, including asthma and allergies. MCs are immune cells found throughout the body …

CircPMS1 promotes proliferation of pulmonary artery smooth muscle cells, pulmonary microvascular endothelial cells, and pericytes under hypoxia

X Hu, S Wang, H Zhao, Y Wei, R Duan… - Animal models and …, 2024 - Wiley Online Library
Abstract Background Circular RNAs (circRNAs) have been recognized as significant
regulators of pulmonary hypertension (PH); however, the differential expression and function …

Clustering analysis and prognostic model based on PI3K/AKT-related genes in pancreatic cancer

X Deng, X He, Z Yang, J Huang, L Zhao, M Wen… - Frontiers in …, 2023 - frontiersin.org
Background Pancreatic cancer is one of most aggressive malignancies with a dismal
prognosis. Activation of PI3K/AKT signaling is instrumental in pancreatic cancer …

[HTML][HTML] KMO in the promotion of tumor development and progression in hepatocellular carcinoma

J Xu, J Song, X Zeng, Y Hu, J Kuang - Journal of Gastrointestinal …, 2023 - ncbi.nlm.nih.gov
Background Hepatocellular carcinoma (HCC) is one of the most common cancers and an
important medical problem with poor prognosis. The role of messenger RNA (mRNA) has …

A microRNA‐clinical prognosis model to predict the overall survival for kidney renal clear cell carcinoma

Y Zhan, R Zhang, C Li, X Xu, K Zhu, Z Yang… - Cancer …, 2021 - Wiley Online Library
Numerous studies have shown that microRNA (miRNA) serves as key regulatory factors in
the origin and development of cancers. However, the biological mechanisms of miRNAs in …