The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …

The insulin-like peptide (ILP) and insulin-like growth factor (IGF) signalling pathways play a
crucial role in the regulation of metabolism, growth and development, fecundity, stress …

Infections and neurodegenerative diseases induce neuroinflammation, but affected
individuals often show nonneural symptoms including muscle pain and muscle fatigue. The …

Summary yki-induced gut tumors in Drosophila are associated with host wasting, including
muscle dysfunction, lipid loss, and hyperglycemia, a condition reminiscent of human cancer …

The deposition of storage fat in the form of triacylglycerol (TAG) is an evolutionarily
conserved strategy to cope with fluctuations in energy availability and metabolic stress …

Macrophages represent the most functionally versatile cells in the animal body. In addition to
recognizing and destroying pathogens, macrophages remove senescent and exhausted …

N‐6‐Methyladenosine (m6A) modification is involved in multiple biological processes
including aging. However, the regulation of m6A methyltransferase‐like 14 (METTL14) in …

Across the animal kingdom, macrophages are known for their functions in innate immunity,
but they also play key roles in development and homeostasis. Recent insights from single …

Maintaining energy homeostasis is critical for ensuring proper growth and maximizing
survival potential of all organisms. Here we review the role of somatic muscle in regulating …

Host–pathogen interactions are shaped by the metabolic status of both the host and
pathogen. The host must regulate metabolism to fuel the immune response, while the …