Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …

This review article describes the pathways and mechanisms of endocytosis and post-
endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family …

When ubiquitin (Ub) is attached to membrane proteins on the plasma membrane, it directs
them through a series of sorting steps that culminate in their delivery to the lumen of the …

Targeting of membrane proteins to their proper destination requires specific mechanisms.
Protein cargos are included in vesicles that bud off a donor organelle and ultimately fuse …

Numerous genetic linkage and association studies implicate members of the Neuregulin-
ErbB receptor (NRG-ErbB) signaling pathway as schizophrenia “at risk” genes. An emphasis …

Neuregulin 1 (NRG1) and ErbB4, critical neurodevelopmental genes, are implicated in
schizophrenia, but the mediating mechanisms are unknown. Here we identify a genetically …

The HECT-type E3 ubiquitin ligase (E3) Itch is absent in the non-agouti-lethal 18H or Itchy
mice, which develop a severe immunological disease, including lung and stomach …

Structural and polymorphic variations in Neuregulin 3 (NRG3), 10q22-23 are associated
with a broad spectrum of neurodevelopmental disorders including developmental delay …

The Hippo tumor suppressor pathway, originally defined in fruit flies, regulates cellular
proliferation and survival and exerts profound effects on normal mammalian cell fate and …