Pathophysiology of eosinophilic esophagitis
KM O'Shea, SS Aceves, ES Dellon, SK Gupta… - Gastroenterology, 2018 - Elsevier
Eosinophilic esophagitis is an emerging disease that is distinguished from
gastroesophageal reflux disease by the expression of a unique esophageal transcriptome …
gastroesophageal reflux disease by the expression of a unique esophageal transcriptome …
Epithelial barrier repair and prevention of allergy
E Goleva, E Berdyshev… - The Journal of clinical …, 2019 - Am Soc Clin Investig
Allergic diseases have in common a dysfunctional epithelial barrier, which allows the
penetration of allergens and microbes, leading to the release of type 2 cytokines that drive …
penetration of allergens and microbes, leading to the release of type 2 cytokines that drive …
[HTML][HTML] Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation
Inflammation of the esophageal epithelium is a hallmark of eosinophilic esophagitis (EoE),
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …
Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study
T Shoda, T Wen, SS Aceves, JP Abonia… - The lancet …, 2018 - thelancet.com
Background Eosinophilic oesophagitis is understood in terms of quantifiable histological,
endoscopic, and molecular features. Data are scant for inter-relations of these features and …
endoscopic, and molecular features. Data are scant for inter-relations of these features and …
Chromatin regulates IL-33 release and extracellular cytokine activity
J Travers, M Rochman, CE Miracle, JE Habel… - Nature …, 2018 - nature.com
IL-33 is an epithelium-derived, pro-inflammatory alarmin with enigmatic nuclear localization
and chromatin binding. Here we report the functional properties of nuclear IL-33 …
and chromatin binding. Here we report the functional properties of nuclear IL-33 …
Type 2 inflammation in eosinophilic esophagitis: from pathophysiology to therapeutic targets
F Racca, G Pellegatta, G Cataldo, E Vespa… - Frontiers in …, 2022 - frontiersin.org
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …
characterized clinically by symptoms related to esophageal dysfunction and histologically by …
Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis
K Laky, JL Kinard, JM Li, IN Moore, J Lack… - Science …, 2023 - science.org
Allergic diseases are a global health challenge. Individuals harboring loss-of-function
variants in transforming growth factor–β receptor (TGFβR) genes have an increased …
variants in transforming growth factor–β receptor (TGFβR) genes have an increased …
Eosinophilic esophagitis: Immune mechanisms and therapeutic targets
D Khokhar, S Marella, G Idelman… - Clinical & …, 2022 - Wiley Online Library
Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …
Breaking down the complex pathophysiology of eosinophilic esophagitis
B Underwood, TD Troutman, JT Schwartz - Annals of Allergy, Asthma & …, 2023 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated disease of
the esophagus associated with antigen-driven type 2 inflammation and symptoms of …
the esophagus associated with antigen-driven type 2 inflammation and symptoms of …
[HTML][HTML] The esophageal organoid system reveals functional interplay between notch and cytokines in reactive epithelial changes
Y Kasagi, PM Chandramouleeswaran… - Cellular and molecular …, 2018 - Elsevier
Background & Aims Aberrations in the esophageal proliferation-differentiation gradient are
histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease …
histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease …