Eosinophilic esophagitis is an emerging disease that is distinguished from
gastroesophageal reflux disease by the expression of a unique esophageal transcriptome …

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the
penetration of allergens and microbes, leading to the release of type 2 cytokines that drive …

Inflammation of the esophageal epithelium is a hallmark of eosinophilic esophagitis (EoE),
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …

Background Eosinophilic oesophagitis is understood in terms of quantifiable histological,
endoscopic, and molecular features. Data are scant for inter-relations of these features and …

IL-33 is an epithelium-derived, pro-inflammatory alarmin with enigmatic nuclear localization
and chromatin binding. Here we report the functional properties of nuclear IL-33 …

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …

Allergic diseases are a global health challenge. Individuals harboring loss-of-function
variants in transforming growth factor–β receptor (TGFβR) genes have an increased …

Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …

Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated disease of
the esophagus associated with antigen-driven type 2 inflammation and symptoms of …

Background & Aims Aberrations in the esophageal proliferation-differentiation gradient are
histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease …