The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …

Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs
detected in the blood of cancer patients is associated with a worse prognosis. CTCs face …

The fact that various immune cells, including macrophages, can be found in tumor tissues
has long been known. With the introduction of concept that macrophages differentiate into a …

The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus,
a great deal of effort has been devoted to the exploration of new technologies to detect early …

Circulating tumor cells, a component of the “liquid biopsy”, hold great potential to transform
the current landscape of cancer therapy. A key challenge to unlocking the clinical utility of …

Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for
studying rare cells and delineating complex populations. Over the past 5 years, SCS …

High lethality rates associated with metastatic cancer highlight an urgent medical need for
improved understanding of biologic mechanisms driving metastatic spread and identification …

Cancer progression is primarily caused by interactions between transformed cells and the
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …

Recent technological advances have enabled the detection and detailed characterization of
circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) in blood samples from …

Modulating immune inhibitory pathways has been a major recent breakthrough in cancer
treatment. Checkpoint blockade antibodies targeting cytotoxic T-lymphocyte antigen 4 …