The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in
nature for millions of years. The human infection, named Chagas disease, is a major public …

Trypanosomes are unable to synthesize the monosaccharide sialic acid, but some African
trypanosomes and the American Trypanosoma cruzi can incorporate sialic acid derived from …

Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the
diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 …

This report of a WHO Expert Committee reviews current knowledge of Chagas disease and
its pathogenesis discusses the causative parasite the triatomine vectors and the natural …

Genetic variation in Trypanosoma cruzi is likely a key determinant in transmission and
pathogenesis of Chagas disease. We have examined nine loci as markers for the extant T …

Abstract Human American trypanosomiasis or Chagas disease—named after Carlos
Chagas who first described it in 1909—exists only on the American continent. It is caused by …

The persistence of Trypanosoma cruzi tissue forms was detected in the myocardium of
seropositive individuals clinically diagnosed as chronic chagasic patients following …

The technique of RNA interference (RNAi) is exceedingly useful for knocking down the
expression of a specific mRNA in African trypanosomes and other organisms for the purpose …

We describe here the identification of eight polymorphic microsatellite loci with (CA) n
repeats in the Trypanosoma cruzi genome based on the affinity capture of fragments using …

Chagas disease (ChD), caused by the hemoflagellate parasite Trypanosoma cruzi, affects
six to seven million people in Latin America. Lately, it has become an emerging public …