Estrogenic endocrine disruptors: Molecular mechanisms of action

R Kiyama, Y Wada-Kiyama - Environment International, 2015 - Elsevier
A comprehensive summary of more than 450 estrogenic chemicals including estrogenic
endocrine disruptors is provided here to understand the complex and profound impact of …

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

EFSA Panel on Food Contact Materials … - EFSA …, 2023 - Wiley Online Library
In 2015, EFSA established a temporary tolerable daily intake (t‐TDI) for BPA of 4 μg/kg body
weight (bw) per day. In 2016, the European Commission mandated EFSA to re‐evaluate the …

[HTML][HTML] Alterations induced by Bisphenol A on cellular organelles and potential relevance on human health

NG Khan, B Tungekar, D Adiga, S Chakrabarty… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Bisphenol A (BPA) is a chemical partially soluble in water and exists in a solid state. Its
structural similarity with estrogen makes it an endocrine-disrupting chemical. BPA can …

Nanostructured lipid carrier-based codelivery of raloxifene and naringin: formulation, optimization, in vitro, ex vivo, in vivo assessment, and acute toxicity studies

A Alhalmi, S Amin, Z Khan, S Beg, O Al Kamaly… - Pharmaceutics, 2022 - mdpi.com
This work aimed to develop dual drug-loaded nanostructured lipid carriers of raloxifene and
naringin (RLX/NRG NLCs) for breast cancer. RLX/NRG NLCs were prepared using …

Fatty acid synthase regulates estrogen receptor-α signaling in breast cancer cells

JA Menendez, R Lupu - Oncogenesis, 2017 - nature.com
Fatty acid synthase (FASN), the key enzyme for endogenous synthesis of fatty acids, is
overexpressed and hyperactivated in a biologically aggressive subset of sex steroid-related …

Bisphenol S negatively affects the meotic maturation of pig oocytes

T Žalmanová, K Hošková, J Nevoral, K Adámková… - Scientific reports, 2017 - nature.com
Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental
pollutant and contaminant of water, air, and food that negatively impacts human health …

Chronic exposure to nonylphenol induces oxidative stress and liver damage in male zebrafish (Danio rerio): Mechanistic insight into cellular energy sensors, lipid …

U Mukherjee, A Samanta, S Biswas, S Ghosh… - Chemico-Biological …, 2022 - Elsevier
Nonylphenol (NP), an environmentally persistent and toxic endocrine-disrupting chemical
with estrogenic properties, has severe implications on humans and wildlife. Accumulating …

Bisphenol A-induced oxidative stress, hepatotoxicity and altered estrogen receptor expression in Labeo bata: impact on metabolic homeostasis and inflammatory …

U Mukherjee, A Samanta, S Biswas, S Das… - Ecotoxicology and …, 2020 - Elsevier
Bisphenol A (BPA), a weak estrogenic endocrine disruptor and a well-known plasticizer, has
the potential to perturb diverse physiological functions; however, its impact on immune and …

Investigation of the effects of subchronic low dose oral exposure to bisphenol A (BPA) and ethinyl estradiol (EE) on estrogen receptor expression in the juvenile and …

ME Rebuli, J Cao, E Sluzas, KB Delclos… - Toxicological …, 2014 - academic.oup.com
Concerns have been raised regarding the long-term impacts of early life exposure to the
ubiquitous environmental contaminant bisphenol A (BPA) on brain organization. Because …

Role of TET dioxygenases and DNA hydroxymethylation in bisphenols-stimulated proliferation of breast cancer cells

Z Li, C Lyu, Y Ren, H Wang - Environmental Health Perspectives, 2020 - ehp.niehs.nih.gov
Background: Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting
estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal …