Teeth develop as ectodermal appendages from epithelial and mesenchymal tissues. Tooth
organogenesis is regulated by an intricate network of cell–cell signaling during all steps of …

Dental agenesis is the most common developmental anomaly in humans and is frequently
associated with several other oral abnormalities. Whereas the incidence of missing teeth …

The skin epidermis and its appendages provide a protective barrier that is impermeable to
harmful microbes and also prevents dehydration. To perform their functions while being …

p63 is a multi-isoform p53 family member required for epidermal development. Contrasting
roles for p63 in either the initial commitment to the stratified epithelial cell fate or in stem cell …

The transcription factor p63 is important in the development of the skin as p63-null mice
exhibit striking defects in embryonic epidermal morphogenesis. Understanding the …

More than 300 genes have so far been associated with tooth development, mainly in mouse
embryos. The majority of them are associated with conserved signaling pathways mediating …

Emerging evidence suggests that cancer is populated and maintained by tumour-initiating
cells (TICs) with stem-like properties similar to those of adult tissue stem cells. Despite …

Abstract p53 mutations, occurring in two-thirds of all human cancers, confer a gain of
function phenotype, including the ability to form metastasis, the determining feature in the …

Epidermal and hair follicle development from surface ectodermal progenitor cells requires
coordinated changes in gene expression. Histone deacetylases alter gene expression …

The p63 gene is a member of the p53/p63/p73 family of transcription factors and plays a
critical role in development and homeostasis of squamous epithelium. p63 is transcribed as …