The association between increased serum urate and hypertension has been a subject of
intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones …

Uric acid is commonly known for its bad reputation. However, it has been shown that uric
acid may be actively involved in neurotoxicity and/or neuroprotection. These effects could be …

Hypoxia limits the survival and function of neurons in the development of Alzheimer's
diseases. Exosome-dependent intercellular communication is an emerging signaling …

Hyperuricemia has been recognized as an independent cardiovascular risk factor in
epidemiological studies. However, uric acid can also exert beneficial functions due to its …

Objectives In patients with gout, maintaining too low serum uric acid (SUA) level with urate-
lowering therapy is a concern because uric acid is thought to be neuroprotective. However …

The average age of hyperuricemia patients has gradually decreased, but young patients
with primary hyperuricemia often do not exhibit clinical symptoms and have not received …

The loss of cognitive function in Alzheimer's disease is pathologically linked with
neurofibrillary tangles, amyloid deposition, and loss of neuronal communication. Cerebral …

An important aspect of survival is to assure enough food, water, and oxygen. Here, we
describe a recently discovered response that favors survival in times of scarcity, and it is …

Abstract Purpose of Review This review aims to summarize recent evidence regarding the
complex relationship between uric acid (UA), gout, and brain diseases. Recent Findings …

Background: This meta-analysis aimed to evaluate the relationship between serum uric acid
(UA) and the risk of dementia and its subtypes. Methods: Embase, PubMed, and Web of …