Evaluation and management of heart failure with preserved ejection fraction

BA Borlaug - Nature Reviews Cardiology, 2020 - nature.com
Heart failure with preserved ejection fraction (HFpEF) has grown to become the dominant
form of heart failure worldwide, in tandem with ageing of the general population and the …

Heart failure with preserved ejection fraction in perspective

MA Pfeffer, AM Shah, BA Borlaug - Circulation research, 2019 - Am Heart Assoc
Approximately half of the patients with signs and symptoms of heart failure have a left
ventricular ejection fraction that is not markedly abnormal. Despite the historically initial …

How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association …

B Pieske, C Tschöpe, RA De Boer… - European heart …, 2019 - academic.oup.com
Making a firm diagnosis of chronic heart failure with preserved ejection fraction (HFpEF)
remains a challenge. We recommend a new stepwise diagnostic process, the 'HFA–PEFF …

Exercise Intolerance in Patients With Heart Failure: JACC State-of-the-Art Review

MG Del Buono, R Arena, BA Borlaug, S Carbone… - Journal of the American …, 2019 - jacc.org
Exercise intolerance is the cardinal symptom of heart failure (HF) and is of crucial relevance,
because it is associated with a poor quality of life and increased mortality. While impaired …

Altered hemodynamics and end-organ damage in heart failure: impact on the lung and kidney

FH Verbrugge, M Guazzi, JM Testani, BA Borlaug - Circulation, 2020 - Am Heart Assoc
Heart failure is characterized by pathologic hemodynamic derangements, including elevated
cardiac filling pressures (“backward” failure), which may or may not coexist with reduced …

Heart failure with preserved ejection fraction: mechanisms and treatment strategies

K Omote, FH Verbrugge… - Annual review of medicine, 2022 - annualreviews.org
Approximately half of all patients with heart failure (HF) have a preserved ejection fraction,
and the prevalence is growing rapidly given the aging population in many countries and the …

Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review

A Pandey, SJ Shah, J Butler, DL Kellogg Jr… - Journal of the American …, 2021 - jacc.org
Exercise intolerance (EI) is the primary manifestation of chronic heart failure with preserved
ejection fraction (HFpEF), the most common form of heart failure among older individuals …

Diastolic dysfunction and heart failure with preserved ejection fraction: understanding mechanisms by using noninvasive methods

M Obokata, YNV Reddy, BA Borlaug - JACC: Cardiovascular Imaging, 2020 - jacc.org
Research in the last decade has substantially advanced our understanding of the
pathophysiology of heart failure with preserved ejection fraction (HFpEF). However …

Latent pulmonary vascular disease may alter the response to therapeutic atrial shunt device in heart failure

BA Borlaug, J Blair, MW Bergmann, H Bugger… - Circulation, 2022 - Am Heart Assoc
Background: In REDUCE LAP-HF II (A Study to Evaluate the Corvia Medical, Inc IASD
System II to Reduce Elevated Left Atrial Pressure in Patients With Heart Failure) …

The haemodynamic basis of lung congestion during exercise in heart failure with preserved ejection fraction

YNV Reddy, M Obokata, B Wiley, KE Koepp… - European heart …, 2019 - academic.oup.com
Aims Increases in extravascular lung water (EVLW) during exercise contribute to symptoms,
morbidity, and mortality in patients with heart failure and preserved ejection fraction …