Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption
AC Haigis, L Vergauwen, CA LaLone… - Toxicological …, 2023 - academic.oup.com
Thyroid hormone system disrupting compounds are considered potential threats for human
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …
[HTML][HTML] Amphibian toxicity testing for identification of thyroid disrupting chemicals
ZC Dang - Environmental Pollution, 2022 - Elsevier
Both amphibian metamorphosis assay (AMA) and larval amphibian growth and
development assay (LAGDA) can detect thyroid-mediated modality and adversity on the …
development assay (LAGDA) can detect thyroid-mediated modality and adversity on the …
Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish
I Van Dingenen, L Vergauwen, AC Haigis… - Aquatic Toxicology, 2023 - Elsevier
Thyroid hormone system disruption (THSD) negatively affects multiple developmental
processes and organs. In fish, inhibition of deiodinases, which are enzymes crucial for (in) …
processes and organs. In fish, inhibition of deiodinases, which are enzymes crucial for (in) …
[HTML][HTML] Gene biomarkers for the assessment of thyroid-disrupting activity in zebrafish embryos
F Essfeld, B Luckner, A Bruder, F Marghany… - Chemosphere, 2024 - Elsevier
Active ingredients of pesticides or biocides and industrial chemicals can negatively affect
environmental organisms, potentially endangering populations and ecosystems. European …
environmental organisms, potentially endangering populations and ecosystems. European …
Testing the sensitivity of the medaka Transgenic Eleuthero-embryonic THYroid-Specific assay (TETHYS) to different mechanisms of action
E Pesce, J Benitez-Gonzalez, AJ Tindall, GF Lemkine… - Aquatic Toxicology, 2024 - Elsevier
There are many concerns about the impacts of Endocrine-Disrupting Chemicals on both
wildlife and human populations. A plethora of chemicals have been shown to interfere with …
wildlife and human populations. A plethora of chemicals have been shown to interfere with …
[HTML][HTML] How the Xenopus eleutheroembryonic thyroid assay compares to the amphibian metamorphosis assay for detecting thyroid active chemicals
D Du Pasquier, B Salinier, KK Coady, A Jones… - Regulatory Toxicology …, 2024 - Elsevier
Abstract The Xenopus Eleutheroembryonic Thyroid Assay (XETA) was recently published as
an OECD Test Guideline for detecting chemicals acting on the thyroid axis. However, the …
an OECD Test Guideline for detecting chemicals acting on the thyroid axis. However, the …
A biologically based computational model for the hypothalamic-pituitary-thyroid (HPT) axis in Xenopus laevis larvae
JT Haselman, JW Nichols, KZ Mattingly… - Mathematical …, 2023 - Elsevier
A biologically based computational model was developed to describe the hypothalamic-
pituitary-thyroid (HPT) axis in developing Xenopus laevis larvae. The goal of this effort was …
pituitary-thyroid (HPT) axis in developing Xenopus laevis larvae. The goal of this effort was …
Combining In Vitro and In Silico New Approach Methods to Investigate Type 3 Iodothyronine Deiodinase Chemical Inhibition Across Species
SA Mayasich, MR Goldsmith… - Environmental …, 2023 - Wiley Online Library
New approach methodologies (NAMs) are being developed to reduce and replace
vertebrate animal testing in support of ecotoxicology and risk assessment. The US …
vertebrate animal testing in support of ecotoxicology and risk assessment. The US …