Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

Action potentials invading the presynaptic terminal trigger discharge of docked synaptic
vesicles (SVs) by opening voltage-dependent calcium channels (CaVs) and admitting …

Dopamine neurons of the substantia nigra pars compacta (SNc) are uniquely sensitive to
degeneration in Parkinson's disease (PD) and its models. Although a variety of molecular …

Synaptic efficacy and precision are influenced by the coupling of voltage-gated Ca 2+
channels (VGCCs) to vesicles. But because the topography of VGCCs and their proximity to …

The coupling between Ca 2+ channels and release sensors is a key factor defining the
signaling properties of a synapse. However, the coupling nanotopography at many …

Introduction Studies of categorical decision-making attempt to understand behavior by
probing how different features of complex and changing environments guide the selection of …

The role of voltage-gated Ca2+ channels (VGCCs) in spontaneous miniature
neurotransmitter release is incompletely understood. We found that stochastic opening of …

How synaptic-vesicle release is controlled at the basic release structure, the active zone, is
poorly understood. By performing cell-attached current and capacitance recordings …

T-type calcium channels represent a key pathway for Ca 2+ entry near the resting
membrane potential. Increasing evidence supports a unique role of these channels in fast …

Hypothalamus is a key area involved in the control of metabolism and food intake via the
integrations of numerous signals (hormones, neurotransmitters, metabolites) from various …