[HTML][HTML] The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS

T McDonnell, C Wincup, I Buchholz, C Pericleous… - Blood reviews, 2020 - Elsevier
Abstract Beta-2-Glycoprotein I (β2GPI) plays a number of essential roles throughout the
body. β2GPI, C-reactive protein and thrombomodulin are the only three proteins that …

Laboratory diagnosis of antiphospholipid syndrome: insights and hindrances

A Vandevelde, KMJ Devreese - Journal of Clinical Medicine, 2022 - mdpi.com
Diagnosis of antiphospholipid syndrome (APS) requires the presence of a clinical criterion
(thrombosis and/or pregnancy morbidity), combined with persistently circulating …

[HTML][HTML] Anti-phospholipid antibodies in COVID-19 are different from those detectable in the anti-phospholipid syndrome

MO Borghi, A Beltagy, E Garrafa, D Curreli… - Frontiers in …, 2020 - frontiersin.org
Background Critically ill patients with coronavirus disease 2019 (COVID-19) have a
profound hypercoagulable state and often develop coagulopathy which leads to organ …

Management of antiphospholipid syndrome

I Uthman, MHA Noureldine, G Ruiz-Irastorza… - Annals of the …, 2019 - ard.bmj.com
Antiphospholipid syndrome, also known as 'Hughes Syndrome', is an autoimmune disease
characterised by a set of clinical manifestations, almost all of which are direct or indirect …

Obstetric and vascular antiphospholipid syndrome: same antibodies but different diseases?

PL Meroni, MO Borghi, C Grossi… - Nature Reviews …, 2018 - nature.com
Recurrent thrombosis and miscarriages are the main clinical manifestations of
antiphospholipid syndrome (APS). Although most patients display both clinical signs, some …

“Non-criteria” antiphospholipid antibodies add value to antiphospholipid syndrome diagnoses in a large Chinese cohort

T Liu, J Gu, L Wan, Q Hu, J Teng, H Liu… - Arthritis research & …, 2020 - Springer
Background Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS)
classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies in addition …

Antiphospholipid antibody assays in 2021: looking for a predictive value in addition to a diagnostic one

PL Meroni, MO Borghi - Frontiers in immunology, 2021 - frontiersin.org
Antiphospholipid antibodies (aPL) are mandatory for the diagnosis but are also a risk factor
for the antiphospholipid syndrome (APS) clinical manifestations. Lupus anticoagulant (LA) …

Obstetric antiphospholipid syndrome

A Antovic, M Sennström, K Bremme… - Lupus science & …, 2018 - lupus.bmj.com
The present clinical and laboratory classification criteria for antiphospholipid syndrome
(APS) were established in Sydney, Australia, in 2006. In this review, we focus on the …

The treatment of anti-phospholipid syndrome: a comprehensive clinical approach

CB Chighizola, L Andreoli, M Gerosa, A Tincani… - Journal of …, 2018 - Elsevier
Anti-phospholipid syndrome (APS) is an acquired pro-thrombotic autoimmune disease that
predisposes to thrombotic events and/or obstetric complications, in the persistent presence …

[HTML][HTML] Role of antiphospholipid antibodies in the diagnosis of antiphospholipid syndrome

KMJ Devreese, S Zuily, PL Meroni - Journal of Translational Autoimmunity, 2021 - Elsevier
The diagnosis of antiphospholipid syndrome (APS) relies on the detection of
antiphospholipid antibodies (aPL). Currently, lupus anticoagulant (LA), anticardiolipin (aCL) …