Rab7 is a small GTPase that belongs to the Rab family and controls transport to late
endocytic compartments such as late endosomes and lysosomes. The mechanism of action …

Endosomes are dynamic intracellular compartments that control the sorting of a constant
stream of different transmembrane cargos either for ESCRT‐mediated degradation or for …

The tubular endolysosomal network is a quality control system that ensures the proper
delivery of internalized receptors to specific subcellular destinations in order to maintain …

The retromer complex has a well-established role in endosomal protein sorting, being
necessary for maintaining the dynamic localisation of hundreds of membrane proteins that …

Due to their post-mitotic state, metabolic demands and often large polarised morphology, the
function and survival of neurons is dependent on an efficient cellular waste clearance …

Intracellular bacterial pathogens subvert the endocytic bactericidal pathway to form specific
replication-permissive compartments termed pathogen vacuoles or inclusions. To this end …

Mitochondria are dynamic organelles regulating metabolism, cell death, and energy
production. Therefore, maintaining mitochondrial health is critical for cellular homeostasis …

Retromer is a membrane coat complex that is recruited to endosomes by the small GTPase
Rab7 and sorting nexin 3. The timing of this interaction and consequent endosomal …

The vacuolar protein sorting 35 (VPS35) gene located on chromosome 16 has recently
emerged as a cause of late-onset familial Parkinson's disease (PD)(PARK17). The gene …

Endosomal sorting is a highly orchestrated cellular process. Retromer is a heterotrimeric
complex that associates with endosomal membranes and facilitates the retrograde sorting of …