Imidazoquinoline derivatives (IMDs) and related compounds function as synthetic agonists
of Toll-like receptors 7 and 8 (TLR7/8) and one is FDA approved for topical antiviral and skin …

This work describes the nature and strength of the immune response induced by various Toll-
like receptor ligands and their ability to act as vaccine adjuvants. It reviews the various …

Topical application of imiquimod (IMQ), a TLR7/8 ligand and potent immune activator, can
induce and exacerbate psoriasis, a chronic inflammatory skin disorder. Recently, a crucial …

Psoriasis is an inflammatory disease of the skin affecting 2–3% of the population,
characterized by a thickening of the epidermis and immune infiltrates throughout the dermis …

Imiquimod is an immune response modifier commercially available as a 3.75 and 5% cream.
Topical imiquimod stimulates the innate and adaptive immune responses and induces …

Aldara is a cream used for topical treatment of non-melanoma skin cancer, and is thought to
act through stimulation of anti-tumour immunity. The active ingredient, imiquimod, has been …

Objective Since imiquimod, a nucleoside analogue of the imidazoquinoline family, has
shown efficacy against many tumour entities, its mode of action has become a focus of …

Psoriasis is a common heterogeneous inflammatory skin disease with a complex
pathophysiology and limited treatment options. Here we performed proteomic analyses of …

Despite advances in treatment and surveillance, melanoma continues to claim
approximately 9,000 lives in the US annually (SEER 2013). The National Comprehensive …

Small-molecule agonists at Toll-like receptor 7 (TLR7) and TLR8 have sparked a vivid
interest in cancer research owing to their profound antitumoral activity. The lead compound …