Human Protein Reference Database (HPRD) is a rich resource of experimentally proven
features of human proteins. Protein information in HPRD includes protein–protein …

Genomic studies of lung adenocarcinoma (LUAD) have advanced our understanding of the
disease's biology and accelerated targeted therapy. However, the proteomic characteristics …

With combined technological advancements in high-throughput next-generation sequencing
and deep mass spectrometry-based proteomics, proteogenomics, ie the integrative analysis …

Background System-wide profiling of genes and proteins in mammalian cells produce lists of
differentially expressed genes/proteins that need to be further analyzed for their collective …

Abstract Knowledge of the various interactions between molecules in the cell is crucial for
understanding cellular processes in health and disease. Currently available interaction …

Kinases determine the phenotypes of many cancer cells, but the frequency with which
individual kinases are activated in primary tumors remains largely unknown. We used a …

Phosphatases are crucially involved in cellular processes by dephosphorylating cellular
components. We describe a structure-based classification scheme for all active human …

Although high-throughput technologies used in biology have resulted in the accumulation of
vast amounts of data in the literature, it is becoming difficult for individual investigators to …

Molecular interactions are key drivers of biological function. Providing interaction resources
to the research community is important since they allow functional interpretation and network …

In mice, Lkb1 deletion and activation of Kras G12D results in lung tumors with a high
penetrance of lymph node and distant metastases. We analyzed these primary and …