International consensus guidance for management of myasthenia gravis: 2020 update

P Narayanaswami, DB Sanders, G Wolfe, M Benatar… - Neurology, 2021 - AAN Enterprises
Objective To update the 2016 formal consensus-based guidance for the management of
myasthenia gravis (MG) based on the latest evidence in the literature. Methods In October …

Advances in the understanding of disease mechanisms of autoimmune neuromuscular junction disorders

MG Huijbers, A Marx, JJ Plomp, R Le Panse… - The Lancet …, 2022 - thelancet.com
Muscle weakness and fatigue are the hallmarks of autoimmune neuromuscular junction
disorders. Although a plethora of immunosuppressive treatments exist, no cure is available …

Current treatment of myasthenia gravis

MK Alhaidar, S Abumurad, B Soliven… - Journal of clinical …, 2022 - mdpi.com
Myasthenia gravis (MG) is the most extensively studied antibody-mediated disease in
humans. Substantial progress has been made in the treatment of MG in the last century …

Novel immunotherapies for myasthenia gravis

SS Nair, S Jacob - ImmunoTargets and therapy, 2023 - Taylor & Francis
Myasthenia gravis (MG), a prototype autoimmune neurological disease, had its therapy
centred on corticosteroids, non-steroidal broad-spectrum immunotherapy and …

Thymus and autoimmunity

A Marx, Y Yamada, K Simon-Keller, B Schalke… - Seminars in …, 2021 - Springer
The thymus prevents autoimmune diseases through mechanisms that operate in the cortex
and medulla, comprising positive and negative selection and the generation of regulatory T …

Role of complement, anti-complement therapeutics, and other targeted immunotherapies in myasthenia gravis

MC Dalakas - Expert Review of Clinical Immunology, 2022 - Taylor & Francis
Introduction Several patients with myasthenia gravis (MG) do not adequately respond to
available drugs or exhibit poor tolerance, necessitating the need for new therapies. Areas …

Guideline for the management of myasthenic syndromes

H Wiendl, A Abicht, A Chan… - Therapeutic …, 2023 - journals.sagepub.com
Myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and congenital
myasthenic syndromes (CMS) represent an etiologically heterogeneous group of (very) rare …

Autoimmune pathology in myasthenia gravis disease subtypes is governed by divergent mechanisms of immunopathology

ML Fichtner, R Jiang, A Bourke, RJ Nowak… - Frontiers in …, 2020 - frontiersin.org
Myasthenia gravis (MG) is a prototypical autoantibody mediated disease. The
autoantibodies in MG target structures within the neuromuscular junction (NMJ), thus …

A practical approach to managing patients with myasthenia gravis—opinions and a review of the literature

ME Farrugia, JA Goodfellow - Frontiers in Neurology, 2020 - frontiersin.org
When the diagnosis of myasthenia gravis (MG) has been secured, the aim of management
should be prompt symptom control and the induction of remission or minimal manifestations …

Diagnosis and treatment of myasthenia gravis

R Mantegazza, P Cavalcante - Current opinion in rheumatology, 2019 - journals.lww.com
CBAs can lead to a significant reduction of seronegative patients, improving myasthenia
gravis diagnostic process. New biological drugs offer innovative approaches to treat …