Anti-PD-(L) 1 therapies yield a disappointing response rate of 15% across soft-tissue
sarcomas, even if some subtypes benefit more than others. The proportions of TAMs and …

Soft tissue sarcoma is a term used to describe a heterogeneous group of many rare tumors.
Since the initial description of activity of doxorubicin, several additional agents have been …

Soft tissue sarcomas (STSs) gather over 80 histological entities, with even more molecular
subsets, characterised by a low to very low incidence in all populations. The majority of …

Background VEGF promotes an immunosuppressive microenvironment and contributes to
immune checkpoint inhibitor resistance in cancer. We aimed to assess the activity of the …

Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment
and follow-up Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis …

Background Angiogenesis is a validated clinical target in advanced epithelial ovarian
cancer. Cediranib is an oral antiangiogenic vascular endothelial growth factor receptor 1–3 …

Soft-tissue sarcoma (STS) is a rare and heterogeneous group of tumours that comprise
approximately 1% of all adult cancers, and encompass over 50 different subtypes. These …

ABSTRACT Background The EORTC-STBSG coordinated two large trials of adjuvant
chemotherapy (CT) in localized high-grade soft tissue sarcoma (STS). Both studies failed to …

Importance Alveolar soft-part sarcoma (ASPS) is a rare, translocation-driven sarcoma of the
soft tissues. Alveolar soft-part sarcoma often affects young adults and is characterized by …

Abstract “Tumor-associated macrophages”(TAMs) form a significant cell population in
malignant tumors and contribute to tumor growth, metastasis, and neovascularization …