▪ Abstract Although well known as the location of the mechanism by which the cardiac
sarcomere is activated by Ca2+ to generate force and shortening, the thin filament is now …

Sixteen years ago, mutations in cardiac troponin (Tn) T and α-tropomyosin were linked to
familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β …

Circular dichroism (CD) is an excellent spectroscopic technique for following the unfolding
and folding of proteins as a function of temperature. One of its principal applications is to …

Tropomyosin is a two-chain α-helical coiled coil whose periodic interactions with the F-actin
helix are critical for thin filament stabilization and the regulation of muscle contraction. Here …

We argue that the overall behavior of tropomyosin on F-actin cannot be easily discerned by
examining thin filaments reduced to their smallest interacting units. In isolation, the …

Wrapped superhelically around actin filaments, the coiled-coil α-helices of tropomyosin
regulate muscle contraction by cooperatively blocking or exposing myosin-binding sites on …

Detailed sequence analyses of the hydrophobic core residues of two long two-stranded α-
helical coiled-coils that differ dramatically in sequence, function, and length were performed …

Tropomyosin is a coiled-coil protein that binds head-to-tail along the length of actin filaments
in eukaryotic cells, stabilizing them and providing protection from severing proteins …

Tropomyosin is the archetypal-coiled coil, yet studies of its structure and function have
proven it to be a dynamic regulator of actin filament function in muscle and non-muscle cells …

Publisher Summary This chapter provides a brief description of tropomyosin's periodic and
aperiodic structural features related to their function. The chapter describes the structure of …