Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact,
venoms are complex mixtures of enzymatic and non-enzymatic components with specific …

Snake venoms are heterogeneous mixtures of proteins and peptides used for prey
subjugation. With modern proteomics there has been a rapid expansion in our knowledge of …

Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …

Wnt dependency and Lgr5 expression define multiple mammalian epithelial stem cell types.
Under defined growth factor conditions, such adult stem cells (ASCs) grow as 3D organoids …

Tumours utilise tryptophan (Trp) and its metabolites to promote their growth and evade host
defences. They recruit Trp through up-regulation of Trp transporters, and up-regulate key …

Snakebite envenomations (SBEs) are a neglected medical condition of global importance
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …

Cancer cells produce abnormal levels of reactive oxygen species (ROS) that contribute to
promote their malignant phenotype. In this framework, we hypothesized that the change in …

Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted
through virus-coded peptides that counteract host cellular immune defense. Although a …

Here we describe and compare the venomic and antivenomic characteristics of both
neonate and adult Prairie Rattlesnake (Crotalus viridis viridis) venoms. Although both …

The human body has a set of physiological processes, known as hemostasis, which keeps
the blood fluid and free of clots in normal vessels; in the case of vascular injury, this process …