Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …

Characterized by a surplus of whole-body adiposity, obesity is strongly associated with the
prognosis of atherosclerosis, a hallmark of coronary artery disease (CAD) and the major …

Objective—Inflammasomes are multiprotein complexes, and their activation has been
associated with cardiovascular disease. Inflammasome activation leads to secretion of …

BACKGROUND: Inflammation contributes to all phases of the atherothrombotic process, and
patients with elevated inflammatory biomarkers such as high-sensitivity C-reactive protein …

There is compelling experimental and clinical evidence suggesting a crucial role for
inflammation in the initiation and also the progression of atherosclerosis. Numerous …

MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular
processes including angiogenesis, apoptosis, proliferation, and migration. Despite great …

Heterogeneity of embryological origins is a hallmark of vascular smooth muscle cells
(SMCs) and may influence the development of vascular disease. Differentiation of human …

Abstract Interleukin (IL)-1 consists of two distinct ligands, IL-1α and IL-1β, with
indistinguishable biological activities that signal through the IL-1 type I receptor (IL-1RI). A …

Oxidative stress and inflammation—two components of the natural host response to injury—
constitute important etiologic factors in atherogenesis. The pro‐inflammatory cytokine …

Adipose tissue is a highly active organ. In addition to storing calories as triglycerides, it also
secretes a large variety of proteins, including cytokines, chemokines and hormone-like …