Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common,
potentially lethal, monogenic diseases and is caused predominantly by mutations in …

Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace
normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease …

Polycystic kidney disease (PKD) is a life-threatening disorder, commonly caused by defects
in polycystin-1 (PC1) or polycystin-2 (PC2), in which tubular epithelia form fluid-filled cysts …

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder
characterized by bilateral renal cyst formation. Recent identification of signaling cascades …

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause
of renal failure. Here we identify miR-17 as a target for the treatment of ADPKD. We report …

Autosomal dominant polycystic kidney disease (ADPKD) is the leading genetic cause of end
stage renal disease characterized by progressive expansion of kidney cysts. To better …

The kidney is permeated by a highly complex vascular system with glomerular and
peritubular capillary networks that are essential for maintaining the normal functions of …

In autosomal dominant polycystic kidney disease (ADPKD) multiple bilateral renal cysts
gradually enlarge, leading to a decline in renal function. Transepithelial chloride secretion …

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder caused by
mutations in PKD1 or PKD2 and affects one in 500–1000 humans. Limited treatment is …

Abstract Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a slowly progressive
disease characterized by the relentless growth of renal cysts throughout the life of affected …