▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

Point mutations in the coding regions of genes are commonly assumed to exert their effects
by altering single amino acids in the encoded proteins. However, there is increasing …

The SR protein family comprises a number of phylogenetically conserved and structurally
related proteins with a characteristic domain rich in arginine and serine residues, known as …

Alternative splicing of human cystic fibrosis transmembrane conductance regulator (CFTR)
exon 9 is regulated by a combination of cis‐acting elements distributed through the exon …

Serine and arginine‐rich (SR) proteins play multiple roles in the eukaryotic gene expression
pathway. Initially described as constitutive and alternative splicing factors, now it is clear that …

Using an in vitro randomization and functional selection procedure, we have identified three
novel classes of exonic splicing enhancers (ESEs) recognized by human SF2/ASF, SRp40 …

▪ Abstract Alternative splicing of pre-mRNAs is a powerful and versatile regulatory
mechanism that can effect quantitative control of gene expression and functional …

Intervening sequences are removed from nuclear pre-mRNAs in a well-defined multi-step
pathway. Small nuclear ribonucleoprotein particles (snRNPs) and numerous protein factors …

DEVELOFMEIST Page 1 VOLUME 10 GENES (Eh DEVELOFMEIST NUMBER 13 PAGES
1569-1710 July 1, 1996 EDITORIAL BOARD J. Adams (Melbourne, Australia) J. Beckwith (Boston …

Metazoan genes are encrypted with at least two superimposed codes: the genetic code to
specify the primary structure of proteins and the splicing code to expand their proteomic …