Mechanisms of long noncoding RNA function in development and disease

SU Schmitz, P Grote, BG Herrmann - Cellular and molecular life sciences, 2016 - Springer
Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …

[HTML][HTML] Induced pluripotent stem cells and their use in human models of disease and development

P Karagiannis, K Takahashi, M Saito… - Physiological …, 2018 - journals.physiology.org
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes

JP Etchegaray, R Mostoslavsky - Molecular cell, 2016 - cell.com
The physiological identity of every cell is maintained by highly specific transcriptional
networks that establish a coherent molecular program that is in tune with nutritional …

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

K Blaschke, KT Ebata, MM Karimi, JA Zepeda-Martínez… - Nature, 2013 - nature.com
DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …

[HTML][HTML] Induced pluripotent stem cells: past, present, and future

S Yamanaka - Cell stem cell, 2012 - cell.com
The development of iPSCs reflected the merging of three major scientific streams and has in
turn led to additional new branches of investigation. However, there is still debate about …

[HTML][HTML] X-inactivation, imprinting, and long noncoding RNAs in health and disease

JT Lee, MS Bartolomei - Cell, 2013 - cell.com
X chromosome inactivation and genomic imprinting are classic epigenetic processes that
cause disease when not appropriately regulated in mammals. Whereas X chromosome …

Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals

R Yin, SQ Mao, B Zhao, Z Chong, Y Yang… - Journal of the …, 2013 - ACS Publications
DNA hydroxymethylation and its mediated DNA demethylation are critical for multiple
cellular processes, for example, nuclear reprogramming, embryonic development, and many …

Stem cell metabolism in tissue development and aging

N Shyh-Chang, GQ Daley, LC Cantley - Development, 2013 - journals.biologists.com
Recent advances in metabolomics and computational analysis have deepened our
appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to …

H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs

J Chen, HE Liu, J Liu, J Qi, B Wei, J Yang, H Liang… - Nature …, 2013 - nature.com
The induction of pluripotent stem cells (iPSCs) by defined factors is poorly understood
stepwise. Here, we show that histone H3 lysine 9 (H3K9) methylation is the primary …

Mechanisms and models of somatic cell reprogramming

Y Buganim, DA Faddah, R Jaenisch - Nature Reviews Genetics, 2013 - nature.com
Conversion of somatic cells to pluripotency by defined factors is a long and complex process
that yields embryonic-stem-cell-like cells that vary in their developmental potential. To …