Thrombin is the key enzyme of the entire hemostatic process since it is able to exert both
procoagulant and anticoagulant functions; therefore, it represents an attractive target for the …

Background: Entomological surveillance for malaria is inherently resource-intensive and
produces crude population-level measures of vector exposure which are insensitive in low …

The anophelins are small protein thrombin inhibitors that are produced in the salivary glands
of the Anopheles mosquito to fulfill a vital role in blood feeding. A bioinformatic analysis of …

The fluorinated alcohol 2, 2, 2-Trifluoroethanol (TFE) has been implemented for many
decades now in conformational studies of proteins and peptides. In peptides, which are …

Background and Purpose Hirudin variants are the most powerful thrombin inhibitors
discovered to date, with a lower risk of bleeding than heparin. For anticoagulation, the C …

Hematophagous organisms produce a suite of salivary proteins which interact with the host's
coagulation machinery to facilitate the acquisition and digestion of a bloodmeal. Many of …

Background Saliva of mosquitoes contains anti-platelet, anti-clotting, vasodilatory, anti-
complement and anti-inflammatory substances that help the blood feeding process. The …

Despite possessing only 32 residues, the tsetse thrombin inhibitor (TTI) is among the most
potent anticoagulants described, with sub-picomolar inhibitory activity against thrombin …

Galectins (Gals) are small cytosolic proteins that bind β-galactoside residues via their
evolutionarily conserved carbohydrate recognition domain. Their dysregulation has been …

The salivary glands of the flea Xenopsylla cheopis, a vector of the plague bacterium,
Yersinia pestis, express proteins and peptides thought to target the hemostatic and …