Proper lamination of the cerebral cortex requires the orchestrated motility of neurons from
their place of birth to their final destination. Improper neuronal migration may result in a wide …

Abstract Hypothyroxinemia affects 35–50% of neonates born prematurely (12% of births)
and increases their risk of suffering neurodevelopmental alterations. We have developed an …

Abstract Treatment-resistant seizures affect about a third of patients suffering from epilepsy.
To fulfill the need for new medications targeting treatment-resistant seizures, a number of …

In this review, we focus on CA3 neuronal migration disorders in the rodent. We begin by
introducing the main steps of hippocampal development, and we summarize characteristic …

Dysfunction of the LIS1 gene causes lissencephaly, a drastic neurological disorder
characterized by a deep disruption of the cortical structure. We aim to uncover alterations of …

LIS1 is one of the principal genes related to Type I lissencephaly, a severe human brain
malformation characterized by an abnormal neuronal migration in the cortex during …

LIS1 (LISSENCEPHALY‐1, also known as PAFAH1B1) is the first gene identified and
reported to be involved in neuronal migration. Multiple studies have demonstrated that LIS1 …

LIS1 (PAFAH1B1) plays a major role in the developing cerebral cortex, and haploinsufficient
mutations cause human lissencephaly type 1. We have studied morphological and …

There is evidence for an association between structural variants in genes for lissencephaly,
which are involved in neuronal migration, and prefrontal cognitive deficits in schizophrenia …

LIS1 is the main causative gene for lissencephaly, while MeCP2 is the main causative gene
for Rett syndrome, both of which are neurodevelopmental diseases. Here we report nuclear …