Nuclear clearance and cytoplasmic mislocalization of the essential RNA binding protein,
TDP-43, is a pathologic hallmark of amyotrophic lateral sclerosis, frontotemporal dementia …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders on a disease spectrum that are characterized by the …

The cytoplasmic aggregation of TAR DNA binding protein-43 (TDP-43), also known as TDP-
43 pathology, is the pathological hallmark of amyotrophic lateral sclerosis (ALS). However …

Aggregation of the RNA‐binding protein TAR DNA‐binding protein 43 (TDP‐43) is the key
neuropathological feature of neurodegenerative diseases, including amyotrophic lateral …

Key early features of amyotrophic lateral sclerosis (ALS) are denervation of neuromuscular
junctions and axonal degeneration. Motor neuron homeostasis relies on local translation …

TDP-43 is an essential RNA-binding protein strongly implicated in the pathogenesis of
neurodegenerative disorders characterized by cytoplasmic aggregates and loss of nuclear …

TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and
amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by …

TAR DNA-binding protein 43, mostly referred to as TDP-43 (encoded by the TARDBP gene)
is strongly linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and …

RNA-binding proteins (RBPs) have emerged as important players in multiple biological
processes including transcription regulation, splicing, R-loop homeostasis, DNA …

In recent years, there has been an emphasis on the role of phase-separated biomolecular
condensates, especially stress granules, in neurodegenerative diseases such as …