Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy
MJ Ramaiah, AD Tangutur, RR Manyam - Life sciences, 2021 - Elsevier
The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …
FOXO transcription factor family in cancer and metastasis
Y Jiramongkol, EWF Lam - Cancer and Metastasis Reviews, 2020 - Springer
Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …
development, metabolism, stem cell maintenance and longevity. They have also been …
Critical role of FOXO3a in carcinogenesis
Y Liu, X Ao, W Ding, M Ponnusamy, W Wu, X Hao… - Molecular cancer, 2018 - Springer
FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a
variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA …
variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA …
[HTML][HTML] Mechanisms of central tolerance for B cells
D Nemazee - Nature Reviews Immunology, 2017 - nature.com
Immune tolerance hinders the potentially destructive responses of lymphocytes to host
tissues. Tolerance is regulated at the stage of immature B cell development (central …
tissues. Tolerance is regulated at the stage of immature B cell development (central …
[HTML][HTML] FOXO signaling pathways as therapeutic targets in cancer
Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …
Molecular and cellular mechanisms of cardiovascular disorders in diabetes
MS Shah, M Brownlee - Circulation research, 2016 - Am Heart Assoc
The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …
ER stress: Autophagy induction, inhibition and selection
HO Rashid, RK Yadav, HR Kim, HJ Chae - Autophagy, 2015 - Taylor & Francis
An accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) leads
to stress conditions. To mitigate such circumstances, stressed cells activate a homeostatic …
to stress conditions. To mitigate such circumstances, stressed cells activate a homeostatic …
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …
[HTML][HTML] Redox regulation of FoxO transcription factors
LO Klotz, C Sánchez-Ramos, I Prieto-Arroyo… - Redox biology, 2015 - Elsevier
Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …
the cellular stress response and promote the cellular antioxidant defense. On one hand …
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
C Settembre, A Fraldi, DL Medina… - Nature reviews Molecular …, 2013 - nature.com
For a long time, lysosomes were considered merely to be cellular'incinerators' involved in
the degradation and recycling of cellular waste. However, now there is compelling evidence …
the degradation and recycling of cellular waste. However, now there is compelling evidence …