The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a
variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA …

Immune tolerance hinders the potentially destructive responses of lymphocytes to host
tissues. Tolerance is regulated at the stage of immature B cell development (central …

Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …

The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …

An accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) leads
to stress conditions. To mitigate such circumstances, stressed cells activate a homeostatic …

Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …

Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …

For a long time, lysosomes were considered merely to be cellular'incinerators' involved in
the degradation and recycling of cellular waste. However, now there is compelling evidence …