Naturally occurring [4+ 2] type terpenoid dimers: sources, bioactivities and total syntheses
B Liu, S Fu, C Zhou - Natural Product Reports, 2020 - pubs.rsc.org
Covering: up to January 2020 [4+ 2] type terpenoid dimers are natural products
biosynthetically derived from [4+ 2] cycloaddition between two terpenoid monomers. They …
biosynthetically derived from [4+ 2] cycloaddition between two terpenoid monomers. They …
ortho‐Quinols in (Bio)Synthesis of Natural Products
M Wloch, E Valzer, L Pouységu… - European Journal of …, 2023 - Wiley Online Library
Alkyl‐6‐hydroxycyclohexa‐2, 4‐dienone derivatives, commonly referred to as ortho‐quinols,
and their simple ester and ether variants constitute a class of organic compounds that …
and their simple ester and ether variants constitute a class of organic compounds that …
Chemical Constituents of Thai Citrus hystrix and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line
S Sun, A Phrutivorapongkul, DF Dibwe… - Journal of natural …, 2018 - ACS Publications
Human pancreatic cancer cells have an extreme tolerance to nutrition starvation, enabling
them to survive in a hypovascular tumor microenvironment. Searching for agents that …
them to survive in a hypovascular tumor microenvironment. Searching for agents that …
Bispericyclic Diels–Alder Dimerization of ortho‐Quinols in Natural Product (Bio)Synthesis: Bioinspired Chemical 6‐Step Synthesis of (+)‐Maytenone
PA Peixoto, M El Assal, I Chataigner… - Angewandte …, 2021 - Wiley Online Library
Many natural products of plant or microbial origins are derived from enzymatic dearomative
oxygenation of 2‐alkylphenolic precursors into 6‐alkyl‐6‐hydroxycyclohexa‐2, 4‐dienones …
oxygenation of 2‐alkylphenolic precursors into 6‐alkyl‐6‐hydroxycyclohexa‐2, 4‐dienones …
6-Thioguanosine monophosphate prodrugs display enhanced performance against thiopurine-resistant leukemia and breast cancer cells
Thiopurines are in widespread clinical use for the treatment of immunological disorders and
certain cancers. However, treatment failure due to resistance or adverse drug reactions are …
certain cancers. However, treatment failure due to resistance or adverse drug reactions are …
4, 5‐Dimethyl‐2‐iodoxybenzenesulfonic acid catalyzed site‐selective oxidation of 2‐substituted phenols to 1, 2‐quinols
M Uyanik, T Mutsuga, K Ishihara - … Chemie International Edition, 2017 - Wiley Online Library
A site‐selective hydroxylative dearomatization of 2‐substituted phenols to either 1, 2‐
benzoquinols or their cyclodimers, catalyzed by 4, 5‐dimethyl‐2‐iodoxybenzenesulfonic …
benzoquinols or their cyclodimers, catalyzed by 4, 5‐dimethyl‐2‐iodoxybenzenesulfonic …
Diastereoselective Biomimetic Synthesis of Dimeric Tetrahydrocarbazoles via a Copper (II)‐Catalyzed Cycloisomerization‐[3+ 2] Cyclodimerization Cascade
The cyclodimerization (homochiral‐and heterochiral−) of monomeric units for the
construction of stereodefined polycyclic systems is a powerful strategy in both biosynthesis …
construction of stereodefined polycyclic systems is a powerful strategy in both biosynthesis …
Total Synthesis of (−)-Bacchopetiolone via an Asymmetric Hydroxylative Phenol Dearomatization/[4+ 2]-Dimerization Cascade Promoted by a Novel Salen-Type …
R Coffinier, ME Assal, PA Peixoto, C Bosset… - Organic …, 2016 - ACS Publications
The first total and biomimetic synthesis of the natural bis (sesquiterpene)(−)-
bacchopetiolone (revised structure) was completed through a highly diastereoselective …
bacchopetiolone (revised structure) was completed through a highly diastereoselective …
Sidechain diversification of grandifloracin allows identification of analogues with enhanced anti‐austerity activity against human PANC‐1 pancreatic cancer cells
BE Alexander, S Sun, MJ Palframan… - …, 2020 - Wiley Online Library
Abstract The natural product (+)‐grandifloracin is a potent “anti‐austerity” agent, able to
suppress the ability of various pancreatic cancer cell lines to tolerate conditions of nutrient …
suppress the ability of various pancreatic cancer cell lines to tolerate conditions of nutrient …
Highly oxygenated antiausterity agents from the leaves of Uvaria dac
From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated
cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine …
cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine …