Naturally occurring [4+ 2] type terpenoid dimers: sources, bioactivities and total syntheses

B Liu, S Fu, C Zhou - Natural Product Reports, 2020 - pubs.rsc.org
Covering: up to January 2020 [4+ 2] type terpenoid dimers are natural products
biosynthetically derived from [4+ 2] cycloaddition between two terpenoid monomers. They …

ortho‐Quinols in (Bio)Synthesis of Natural Products

M Wloch, E Valzer, L Pouységu… - European Journal of …, 2023 - Wiley Online Library
Alkyl‐6‐hydroxycyclohexa‐2, 4‐dienone derivatives, commonly referred to as ortho‐quinols,
and their simple ester and ether variants constitute a class of organic compounds that …

Chemical Constituents of Thai Citrus hystrix and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line

S Sun, A Phrutivorapongkul, DF Dibwe… - Journal of natural …, 2018 - ACS Publications
Human pancreatic cancer cells have an extreme tolerance to nutrition starvation, enabling
them to survive in a hypovascular tumor microenvironment. Searching for agents that …

Bispericyclic Diels–Alder Dimerization of ortho‐Quinols in Natural Product (Bio)Synthesis: Bioinspired Chemical 6‐Step Synthesis of (+)‐Maytenone

PA Peixoto, M El Assal, I Chataigner… - Angewandte …, 2021 - Wiley Online Library
Many natural products of plant or microbial origins are derived from enzymatic dearomative
oxygenation of 2‐alkylphenolic precursors into 6‐alkyl‐6‐hydroxycyclohexa‐2, 4‐dienones …

6-Thioguanosine monophosphate prodrugs display enhanced performance against thiopurine-resistant leukemia and breast cancer cells

S Moreno, M Fickl, I Bauer, M Brunner… - Journal of Medicinal …, 2022 - ACS Publications
Thiopurines are in widespread clinical use for the treatment of immunological disorders and
certain cancers. However, treatment failure due to resistance or adverse drug reactions are …

4, 5‐Dimethyl‐2‐iodoxybenzenesulfonic acid catalyzed site‐selective oxidation of 2‐substituted phenols to 1, 2‐quinols

M Uyanik, T Mutsuga, K Ishihara - … Chemie International Edition, 2017 - Wiley Online Library
A site‐selective hydroxylative dearomatization of 2‐substituted phenols to either 1, 2‐
benzoquinols or their cyclodimers, catalyzed by 4, 5‐dimethyl‐2‐iodoxybenzenesulfonic …

Diastereoselective Biomimetic Synthesis of Dimeric Tetrahydrocarbazoles via a Copper (II)‐Catalyzed Cycloisomerization‐[3+ 2] Cyclodimerization Cascade

D Roy, B Baire - Angewandte Chemie International Edition, 2023 - Wiley Online Library
The cyclodimerization (homochiral‐and heterochiral−) of monomeric units for the
construction of stereodefined polycyclic systems is a powerful strategy in both biosynthesis …

Total Synthesis of (−)-Bacchopetiolone via an Asymmetric Hydroxylative Phenol Dearomatization/[4+ 2]-Dimerization Cascade Promoted by a Novel Salen-Type …

R Coffinier, ME Assal, PA Peixoto, C Bosset… - Organic …, 2016 - ACS Publications
The first total and biomimetic synthesis of the natural bis (sesquiterpene)(−)-
bacchopetiolone (revised structure) was completed through a highly diastereoselective …

Sidechain diversification of grandifloracin allows identification of analogues with enhanced anti‐austerity activity against human PANC‐1 pancreatic cancer cells

BE Alexander, S Sun, MJ Palframan… - …, 2020 - Wiley Online Library
Abstract The natural product (+)‐grandifloracin is a potent “anti‐austerity” agent, able to
suppress the ability of various pancreatic cancer cell lines to tolerate conditions of nutrient …

Highly oxygenated antiausterity agents from the leaves of Uvaria dac

S Awale, AM Tawila, DF Dibwe, J Ueda, S Sun… - Bioorganic & Medicinal …, 2017 - Elsevier
From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated
cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine …