The need for new antibacterial drugs to treat the increasing global prevalence of drug-
resistant bacterial infections has clearly attracted global attention, with a range of existing …

Nanoparticles with their various physical and chemical properties are commonly applied in
the environmental remediation systems, as well as in the field of biomedicine. We report the …

Antibiotics have profoundly revolu-tionized medicine and the health care sector since
Alexander Fleming first identified the bacteria-killing properties of penicillin. The following …

Aminoglycosides (AGs) are long-known molecules successfully used against Gram-negative
pathogens. While their use declined with the discovery of new antibiotics, they are now …

Background Resistance burden varies widely among WHO regions, and the potential impact
of new antibiotics differs in addressing the WHO's critical priority pathogens' resistance …

Covering: 1992 up to 2023 Since their discovery, lasso peptides went from peculiarities to
be recognized as a major family of ribosomally synthesized and post-translationally modified …

Antimicrobial resistance continues to increase globally and treatment of difficult-to-treat
(DTT) infections, mostly associated with carbapenem-resistant (CR) Pseudomonas …

The hybridization of heterocycles presents a key opportunity to craft innovative multicyclic
compounds with enhanced biological activity. Coumarins, being broadly prevalent natural …

Biosynthetic engineering of bicyclic darobactins, selectively sealing the lateral gate of the
outer membrane protein BamA, leads to active analogues, which are up to 128-fold more …

Antibiotic-resistant genes (ARGs) have emerged in water bodies due to the discharge of
huge amounts of antibiotics into wastewater. Well-planned and designed configurational …