Abstract Background Prader–Willi syndrome (PWS) is a complex neuroendocrine disorder
affecting approximately 1/15,000–1/30,000 people. Unmet medical needs of individuals with …

Emerging evidence has suggested a possible physiologic role for peripheral glucagon-like
peptide 1 (GLP-1) in regulating glucose metabolism and food intake. The likely site of action …

The Cannabinoid CB1 Receptor (CB1R) is involved in a variety of physiological pathways
and has long been considered a golden target for therapeutic manipulation. A large body of …

The endocannabinoid system is involved in a wide range of processes including the control
of energy acquisition and expenditure. Endocannabinoids and their receptors are present in …

The peripheral peptide hormone ghrelin is a powerful stimulator of food intake, which leads
to body weight gain and adiposity in both rodents and humans. The hormone, thus …

The cannabinoid 1 (CB1) receptor regulates appetite and body weight; however, unwanted
central side effects of both agonists (in wasting disorders) or antagonists (in obesity and …

Maintenance of body weight is fundamental to maintain one's health and to promote
longevity. Nevertheless, it appears that the global obesity epidemic is still constantly …

The growth hormone secretagogue receptor (GHSR) and the cannabinoid receptor type 1
(CB1R) are G-protein coupled receptors highly expressed in the brain and involved in …

Rationale Ghrelin is a fast-acting hormone that is produced primarily by the stomach and by
the brain although in smaller quantities. The regulation and the secretion of ghrelin are …

Over the years, the knowledge regarding the relevance of the cannabinoid system to the
regulation of metabolism has grown steadily. A central interaction between the cannabinoid …