Signal transducer and activator of transcription (STAT) 3 and STAT5 are important
transcription factors that are able to mediate or even drive cancer progression through …

The transcription factors STAT5A and STAT5B have essential roles in survival and
proliferation of hematopoietic cells—which have been considered largely redundant …

Introduction Previous studies suggest that monocytes are an important contributor to
tuberculosis (TB)-specific immune signatures in blood. Methods Here, we carried out …

Simple Summary Ovarian cancer remains the deadliest cancer of the female reproductive
system. There is a significant body of evidence that has demonstrated that Signal …

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway
functions as a central hub for transmitting signals from more than 50 cytokines, playing a …

Introduction Experimental and virtual screening contributes to the discovery of more than
50% of clinical candidates. Considering the similar concept and goals, early-phase drug …

Background: Glioblastoma (GBM) is characterized by abundant neovascularization as an
essential hallmark. Vasculogenic mimicry (VM) is a predominant pattern of GBM …

Introduction Inhibition of STAT5 was recently reported to reduce murine atherosclerosis.
However, the role of STAT5 isoforms, and more in particular STAT5A in macrophages in the …

The transcription factors STAT5a and STAT5b are constitutively active in many human
tumors. Combined inhibition of both STAT5 proteins is a valuable approach with promising …

The signal transducer and activation of transcription (STAT) proteins are a family of Src
homology 2 (SH2) domain-containing transcription factors. The family member STAT4 is a …